Aquaporin-mediated dysregulation of cell migration in disease states

Dysregulated cell migration and invasion are hallmarks of many disease states. This dysregulated migratory behavior is influenced by the changes in expression of aquaporins (AQPs) that occur during pathogenesis, including conditions such as cancer, endometriosis, and arthritis. The ubiquitous function of AQPs in migration of diseased cells makes them a crucial target for potential therapeutics; this possibility has led to extensive research into the specific mechanisms underlying AQP-mediated diseased cell migration. The functions of AQPs depend on a diverse set of variables including cell type, AQP isoform, disease state, cell microenvironments, and even the subcellular localization of AQPs. To consolidate the considerable work that has been conducted across these numerous variables, here we summarize and review the last decade’s research covering the role of AQPs in the migration and invasion of cells in diseased states. Similar content being viewed by others Availability of data and material Not applicable because this review paper does not contain any original data.

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No additional acknowledgements beyond funding sources. Funding The authors acknowledge funding from an NIGMS MIRA #R35GM142838 (to KMS) and from the Clark Doctoral Fellowship (to IMS and SB). Research reported in this publication was supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number R35GM142838. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Author information Authors and Affiliations Contributions IMS and KMS conceived of the topic. IMS drafted the majority of the manuscript and created the figures. SB drafted section 3 of the manuscript. AKM helped prepare Tables 1 and 2. KMS edited the manuscript and supervised the project. All authors edited the manuscript and approved the final version. Corresponding author Ethics declarations Conflict of interest The authors have no financial or non-financial interests to declare. Ethical approval and consent to participate Not applicable. Consent for publication Not applicable. Additional information Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Rights and permissions Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. About this article Cite this article Smith, I.M., Banerjee, S., Moses, A.K. et al. Aquaporin-mediated dysregulation of cell migration in disease states. Cell. Mol. Life Sci. 80, 48 (2023). https://doi.org/10.1007/s00018-022-04665-9 Received: Revised: Accepted: Published: Version of record: DOI: https://doi.org/10.1007/s00018-022-04665-9