{"paper_id":"ddb6d22d-6f4b-4656-beca-7dbfee72b776","body_text":"Abstract\nDysregulated cell migration and invasion are hallmarks of many disease states. This dysregulated migratory behavior is influenced by the changes in expression of aquaporins (AQPs) that occur during pathogenesis, including conditions such as cancer, endometriosis, and arthritis. The ubiquitous function of AQPs in migration of diseased cells makes them a crucial target for potential therapeutics; this possibility has led to extensive research into the specific mechanisms underlying AQP-mediated diseased cell migration. The functions of AQPs depend on a diverse set of variables including cell type, AQP isoform, disease state, cell microenvironments, and even the subcellular localization of AQPs. 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Toxicol Sci 149(1):158–166\nAcknowledgements\nNo additional acknowledgements beyond funding sources.\nFunding\nThe authors acknowledge funding from an NIGMS MIRA #R35GM142838 (to KMS) and from the Clark Doctoral Fellowship (to IMS and SB). Research reported in this publication was supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number R35GM142838. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.\nAuthor information\nAuthors and Affiliations\nContributions\nIMS and KMS conceived of the topic. IMS drafted the majority of the manuscript and created the figures. SB drafted section 3 of the manuscript. AKM helped prepare Tables 1 and 2. KMS edited the manuscript and supervised the project. All authors edited the manuscript and approved the final version.\nCorresponding author\nEthics declarations\nConflict of interest\nThe authors have no financial or non-financial interests to declare.\nEthical approval and consent to participate\nNot applicable.\nConsent for publication\nNot applicable.\nAdditional information\nPublisher's Note\nSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nRights and permissions\nSpringer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.\nAbout this article\nCite this article\nSmith, I.M., Banerjee, S., Moses, A.K. et al. Aquaporin-mediated dysregulation of cell migration in disease states. Cell. Mol. Life Sci. 80, 48 (2023). https://doi.org/10.1007/s00018-022-04665-9\nReceived:\nRevised:\nAccepted:\nPublished:\nVersion of record:\nDOI: https://doi.org/10.1007/s00018-022-04665-9","source_license":"CC-BY-4.0","license_restricted":false}