Vaginal disinfection with povidone iodine immediately before oocyte retrieval is effective in preventing pelvic abscess formation without compromising the outcome of IVF-ET

Yung-Chieh Tsai, Mike Y S Lin, Sheng-Hsieg Chen, Ming-Ting Chung, Tao-Chuan Loo, Kuo-Feng Huang, Liang-Yin Lin
Journal of assisted reproduction and genetics · 2005 · doi:10.1007/s10815-005-4915-5 · PMID:16021862 · PMC3455288
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Vaginal douching with povidone iodine before oocyte retrieval prevented pelvic abscesses in IVF patients without negatively impacting fertilization, implantation, or pregnancy rates.

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This retrospective study evaluated whether aqueous povidone iodine vaginal douching immediately before oocyte retrieval could reduce pelvic abscess formation in patients with ovarian endometrioma undergoing IVF-ET, without reducing reproductive outcomes. Patients were classified by the vaginal douching solution used immediately before retrieval, and the study compared fertilization rate, implantation rate, and clinical pregnancy rate between the two groups. The fertilization rate, implantation rate, and clinical pregnancy rate did not differ significantly, while pelvic abscess occurred in two cases in the povidone iodine group and none in the other group. The authors conclude the disinfection approach is effective at preventing pelvic infection without compromising IVF-ET outcomes, while the retrospective classification serves as a key limitation. This paper is centrally about endometriosis — it specifically studies IVF-ET patients with ovarian endometrioma and addresses prevention of pelvic abscess related to oocyte retrieval in that endometriosis context.

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Abstract

PURPOSE: In this study, the method of employing preretrieval vaginal douching with aqueous povidone iodine is examined to see if it can decrease the incidence of pelvic abscess without compromising the clinical outcome of IVF-ET. METHODS: Patients with ovarian endometrioma and received IVF-ET treatment were retrospectively classified into two groups according to the difference of vaginal douching solution immediately before oocyte retrieval. RESULTS: There was no difference in the fertilization rate (81.2% versus 79.8%, P > 0.05), implantation rate (19.2% versus 23.3%, P > 0.05), clinical pregnancy rate (39.3% versus 46.2%, P > 0.05) between the two groups. There was no infection in patients of group two but two cases in group one developed pelvic abscess and needed surgical intervention. CONCLUSIONS: Vaginal douching with aqueous povidone iodine followed by normal saline irrigation immediately before oocyte retrieval is effective in preventing the pelvic infection without compromising the outcome of IVF treatment.
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Abstract

Purpose: In this study, the method of employing pre-retrieval vaginal douching with aqueous povidone iodine is examined to see if it can decrease the incidence of pelvic abscess without compromising the clinical outcome of IVF-ET.

Methods

Patients with ovarian endometrioma and received IVF-ET treatment were retrospectively classified into two groups according to the difference of vaginal douching solution immediately before oocyte retrieval.

Results

There was no difference in the fertilization rate (81.2% versus 79.8%, P > 0.05), implantation rate (19.2% versus 23.3%, P > 0.05), clinical pregnancy rate (39.3% versus 46.2%, P > 0.05) between the two groups. There was no infection in patients of group two but two cases in group one developed pelvic abscess and needed surgical intervention.

Conclusions

Vaginal douching with aqueous povidone iodine followed by normal saline irrigation immediately before oocyte retrieval is effective in preventing the pelvic infection without compromising the outcome of IVF treatment.

References

Dicker D, Ashkenazi J, Feldberg D, Levy T, Dekel A, Ben-Rafael Z: Severe abdominal complications after transvaginal ultrasonographically guided retrieval of oocytes for in vitro fertilization and embryo transfer. Fertil Steril 1993;59:1313–1315 Bennett SJ, Waterstone JJ, Cheng WC, Parsons J: Complications of transvaginal ultrasound-directed follicle aspiration: a review of 2670 consecutive procedures. J Assist Reprod Genet 1993;10:72–77 Padilla SL: Ovarian abscess following puncture of an endometrioma during ultrasound-guided oocyte retrieval. Hum Reprod 1993;8:1282–1283 Younis JS, Ezra Y, Laufer N, Ohel G: Late manifestation of pelvic abscess following oocyte retrieval, for in vitro fertilization, in patients with severe endometriosis and ovarian endometriomata. J Assist Reprod Genet 1997;14:343–346 Tsai YC, Chung MT, Sung YH, Tsai TF, Tsai YT, Lin LY: Clinical value of early cleavage embryo. Int J Gynecol Obstet 2002:F76(3):293–297 Howe RS, Wheeler C, Mastroianni L Jr, Blasco L, Tureck R: Pelvic infection after transvaginal ultrasound-guided ovum retrieval. Fertil Steril 1988;49:726–728 Meldrum DR: Antibiotics for vaginal oocyte aspiration. J In Vitro Fert Embryo Transf 1989;6:1–2 Kubota T, Ishi K, Takeuchi H: A study of tubo-ovarian and ovarian abscesses, with a focus on cases with endometrioma. J Obstet Gynaecol Res 1997;23:421–426 Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Tsai, YC., Lin, M.Y.S., Chen, SH. et al. Vaginal disinfection with povidone iodine immediately before oocyte retrieval is effective in preventing pelvic abscess formation without compromising the outcome of IVF-ET. J Assist Reprod Genet 22, 173–175 (2005). https://doi.org/10.1007/s10815-005-4915-5 Received: Accepted: Issue date: DOI: https://doi.org/10.1007/s10815-005-4915-5

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Condition tags

endometriosisendometrioma

MeSH descriptors

Abscess Disinfection Embryo Transfer Fertilization in Vitro Fertilization in Vitro Pelvic Infection Pharmaceutic Aids Povidone Abscess Abscess Adult Disinfection Embryo Transfer Endometriosis Endometriosis Female Fertilization in Vitro Humans Infertility, Female Infertility, Female

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