Impact of ovarian diseases on fertility reserve as assessed through serum AMH levels in reproductive age women

Nisha Singh, Shubhangi Srivastava, Nidhi Singh, Wahid Ali
In: Journal of Endometriosis and Uterine Disorders · 2023 · vol. 4 , pp. 100051 · doi:10.1016/j.jeud.2023.100051 · W4388915047
article OA: diamond CC0
🔓 Open OA copy View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-11 ⓘ

This study found that ovarian cancer and endometriomas significantly reduced serum AMH levels, indicating a diminished fertility reserve, while other benign ovarian diseases did not.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The aim of this study was to assess the effect of ovarian diseases on fertility reserve evaluating serum Anti-Mullerian Hormone (AMH) levels. This was a prospective study conducted on 66 reproductive age patients operated for an ovarian mass in the Department of Obstetrics and Gynaecology of a tertiary care teaching hospital in North India. The study included n = 18 cases of ovarian cancer, n = 20 cases of endometrioma and n = 28 cases of other benign ovarian disease. 5 ml of venous blood sample was obtained prior to surgical intervention for serum AMH analysis. Fertility sparing surgeries were done in n = 48 cases and n = 18 cases underwent radical surgeries. Histopathology (HPE) reports were recorded for all cases post-surgery. Serum AMH was correlated with HPE report to see the effect of various ovarian diseases on fertility status. Serum AMH levels in malignant (0.34 ± 0.44 ng/ml) and endometrioma cases (1.50 ± 0.62 ng/ml) were significantly lower (p < 0.05) as compared to those found in cases affected by other inflammatory/benign cyst (3.93 ± 4.76 ng/ml). Ovarian cancer cases had the lowest serum AMH value (0.34 ± 0.44 ng/ml), well below the normal range. Ovarian cancer has an important adverse effect on ovarian fertility reserve, greater than endometriomas. Other benign ovarian tumors do not affect fertility reserve.

My notes (saved in your browser only)

Condition tags

endometrioma

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (22)

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK