The Diagnostic Superiority of the HE-4 Marker over CA-125 and CA 19-9 in the Differentiation of a Large Pelvic Tumor – a Case Report

Anita Chudecka-Głaz, Janusz Menkiszak, Aneta Cymbaluk‐Płoska, Donald Rutkowski, Miłosz Kawa, Grażyna Wilk
In: Journal of Endometriosis and Pelvic Pain Disorders · 2013 · vol. 5(1) , pp. 40–45 · doi:10.5301/je.5000150 · W2016846007
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This case report demonstrates the HE-4 marker's diagnostic superiority over CA-125 and CA 19-9 in differentiating a large pelvic tumor, highlighting its utility in complex cases like advanced endometriosis versus ovarian malignancy.

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Abstract

The HE-4 protein is a promising specific marker for the diagnosis of malignant pelvic tumors. The paper presents the case of a 41-year-old patient with a multi-chamber ovarian tumor several centimeters in diameter suspected to be a primary ovarian cancer or a metastatic one of gastrointestinal origin. The value of the HE-4 marker which is highly specific for an ovarian cancer was within normal limits and amounted to 24.33 pmol/L. The patient underwent surgery involving the unilateral removal of adnexa and the greater omentum during which the sample from the second ovary was collected. Histologic examination revealed ovarian endometriosis; however, diagnosis of the gastrointestinal tract did not reveal any abnormalities. The case presented also confirms the excellent sensitivity of the HE-4 marker in very difficult clinical cases, as well as its utility in the differential diagnosis of advanced endometriosis and malignant ovarian diseases.

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endometriosis

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