Micronized palmitoylethanolamide/trans-polydatin treatment of endometriosis-related pain: a meta-analysis

Ugo Indraccolo, Indraccolo U, S R Indraccolo, Indraccolo SR, Salvatore Renato Indraccolo, Mignini F, Fiorenzo Mignini
Annali dell'Istituto superiore di sanita · 2018 · vol. 53(2) , pp. 125–134 · doi:10.4415/ann_17_02_08 · PMID:28617258 · W2729108066
Systematic review / meta-analysis OA: green CC0 ⤵ 6 in-corpus citations
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This meta-analysis of four low-quality studies found that micronized palmitoylethanolamide/trans-polydatin improved chronic pelvic pain and dysmenorrhea in endometriosis patients, but had limited effect on deep dyspareunia and no effect on dyschezia.

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Abstract

AIM: To demonstrate clinical effectiveness of micronized palmitoylethanolamide-trans-polydatin combination in reducing endometriotic chronic pelvic pain. Other endometriotic-pains were also assessed. METHODS: Systematic reviews of PubMed, SCIELO, Scopus, and AJOL. Randomized trials and observational studies reporting a visual analogue scale for pain or similar in endometriotic patients were reviewed. A mean improvement of visual analogue scale (or visual analogue scale-like) scores at enrollment and at a three-month follow-up was assessed and interpreted clinically. RESULTS: Four studies of poor quality were available. In a heterogeneous sample of endometriotic patients with pain, the administration of micronized palmitoylethanolamide/trans-polydatin (400 mg/40 mg) twice a day for three months provided a clinically relevant improvement of chronic pelvic pain and dysmenorrhea while improving deep dyspareunia to a limited degree. No clinically relevant improvement was found for dyschezia. CONCLUSION: More studies are warranted for assessing the drugs-related efficacy.

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Condition tags

endometriosischronic_pelvic_paindysmenorrheadyspareunia

MeSH descriptors

Endometriosis Endometriosis Ethanolamines Glucosides Pain Pain Palmitic Acids Stilbenes Amides Amides Drug Combinations Drug Combinations Endometriosis Endometriosis Ethanolamines Ethanolamines Female Female Glucosides Glucosides

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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