Micronized palmitoylethanolamide/trans-polydatin treatment of endometriosis-related pain: a meta-analysis.

Ugo Indraccolo, Salvatore Renato Indraccolo, S R Indraccolo, Fiorenzo Mignini
Annali dell'Istituto superiore di sanita · 2018 · vol. 53(2) , pp. 125–134 · doi:10.4415/ann_17_02_08 · PMID:28617258 · W2729108066
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This meta-analysis of four low-quality studies found that micronized palmitoylethanolamide/trans-polydatin improved chronic pelvic pain and dysmenorrhea in endometriosis patients, but had limited effect on deep dyspareunia and no effect on dyschezia.

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Abstract

AIM: To demonstrate clinical effectiveness of micronized palmitoylethanolamide-trans-polydatin combination in reducing endometriotic chronic pelvic pain. Other endometriotic-pains were also assessed. METHODS: Systematic reviews of PubMed, SCIELO, Scopus, and AJOL. Randomized trials and observational studies reporting a visual analogue scale for pain or similar in endometriotic patients were reviewed. A mean improvement of visual analogue scale (or visual analogue scale-like) scores at enrollment and at a three-month follow-up was assessed and interpreted clinically. RESULTS: Four studies of poor quality were available. In a heterogeneous sample of endometriotic patients with pain, the administration of micronized palmitoylethanolamide/trans-polydatin (400 mg/40 mg) twice a day for three months provided a clinically relevant improvement of chronic pelvic pain and dysmenorrhea while improving deep dyspareunia to a limited degree. No clinically relevant improvement was found for dyschezia. CONCLUSION: More studies are warranted for assessing the drugs-related efficacy.

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Condition tags

endometriosischronic_pelvic_paindysmenorrheadyspareunia

MeSH descriptors

Endometriosis Endometriosis Ethanolamines Glucosides Pain Pain Palmitic Acids Stilbenes Amides Drug Combinations Endometriosis Ethanolamines Female Glucosides Humans Pain Pain Management Palmitic Acids Stilbenes

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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