Effect of Levonorgestrel-Releasing Intrauterine System in the Treatment of Adenomyosis

Objective:To evaluate the clinical effect of levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of adenomyosis.Methods:One hundred-two patients with adenomyosis were treated with LNG-IUS,and the menstrual patterns,severity of dysmenorrhea and side effects were observed at baseline and 1,3,6,12 months after treating with LNG-IUS.Results:①102 cases were followed after device insertion,8 cases requested removal of the device(5 for oligomenorrhea,and 3 for acne).At 12 months,the overall continuation rate was 92.16%(94/102);②The VAS and VRS of dysmenorrhea dropped continuously and significantly after the LNG-IUS insertion (P0.05);③Oligomenorrhea occurred in 68.63%,78.43% and 91.49% patients at 1,3,12 months after insertion,respectively.④Irregular bleeding was the main side effect,which occurred in 19 women 1 month after insertion and in 12 women 3 months after insertion.After 6 months of observation,irregular bleeding was not present in any patient.In addition,6 women reported amenorrhea in 12 months after insertion.Conclusions:LNG-IUS is an effective method for controlling the symptoms of adenomyosis in one year's observation.