Histone deacetylase inhibitors down-regulate G-protein-coupled estrogen receptor and the GPER-antagonist G-15 inhibits proliferation in endometriotic cells

Abstract

OBJECTIVE: To investigate whether histone deacetylase inhibitors reduce the expression of the G-protein-coupled estrogen receptor (GPER) and whether the functional inhibition of GPER by the antagonist G-15 decreases the proliferation of endometriotic cells. DESIGN: In vitro study. SETTING: University hospital. PATIENT(S): Immortalized epithelial endometriotic cells. INTERVENTION(S): Treatment with the histone deacetylase inhibitor romidepsin or suberoylanilide hydroxamic acid (SAHA), or with the GPER antagonist G-15. MAIN OUTCOME Metrics Views Additional indexing Creators (Authors) Volume Volume Volume Number Number Number Page range/Item number Page range/Item number Page range/Item number Page end Page end Page end Item Type Item Type Item Type In collections Dewey Decimal Classifikation Dewey Decimal Classifikation Dewey Decimal Classifikation Language Language Language Publication date Publication date Publication date Date available Date available Date available ISSN or e-ISSN ISSN or e-ISSN ISSN or e-ISSN OA Status OA Status OA Status Publisher DOI Metrics Views Citations Imesch, P., Samartzis, E. P., Dedes, K. J., Fink, D., & Fedier, A. (2013). Histone deacetylase inhibitors down-regulate G-protein-coupled estrogen receptor and the GPER-antagonist G-15 inhibits proliferation in endometriotic cells. Fertility and Sterility, 100, 770–776. https://doi.org/10.1016/j.fertnstert.2013.05.008