A novel and compact review on the role of oxidative stress in female reproduction

Jiayin Lu, Zixu Wang, Jing Cao, Yaoxing Chen, Yulan Dong
Reproductive biology and endocrinology : RB&E · 2018 · doi:10.1186/s12958-018-0391-5 · PMID:30126412 · PMC6102891
review OA: gold CC-BY-4.0
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Abstract

In recent years, the study of oxidative stress (OS) has become increasingly popular. In particular, the role of OS on female fertility is very important and has been focused on closely. The occurrence of OS is due to the excessive production of reactive oxygen species (ROS). ROS are a double-edged sword; they not only play an important role as secondary messengers in many intracellular signaling cascades, but they also exert indispensable effects on pathological processes involving the female genital tract. ROS and antioxidants join in the regulation of reproductive processes in both animals and humans. Imbalances between pro-oxidants and antioxidants could lead to a number of female reproductive diseases. This review focuses on the mechanism of OS and a series of female reproductive processes, explaining the role of OS in female reproduction and female reproductive diseases caused by OS, including polycystic ovary syndrome (PCOS), endometriosis, preeclampsia and so on. Many signaling pathways involved in female reproduction, including the Keap1-Nrf2, NF-κB, FOXO and MAPK pathways, which are affected by OS, are described, providing new ideas for the mechanism of reproductive diseases.

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Condition tags

endometriosis

MeSH descriptors

Genital Diseases, Female Oxidative Stress Reactive Oxygen Species Reproduction Animals Female Genital Diseases, Female Humans Infertility, Female Infertility, Female Pregnancy Reactive Oxygen Species

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SciLite annotations

chemicals 60
oxygen oxygen superoxide anion hydroxyl hydroperoxyl hydroperoxyl electron carbohydrate water alcohol vitamin c vitamin e amyloid-beta selenium zinc taurine glutathione oxygen hydroperoxide glutathione glutathione oxygen superoxide hydrogen peroxide lipid hydroperoxide oxygen oxygen vitamin e lipid lipid tocopherol ascorbic acid amyloid-beta vitamin e amyloid-beta oxygen vitamin e amyloid-beta oxygen oxygen superoxide hydrogen peroxide hydroxyl lipid progesterone progesterone glucose fatty acid hydroxyl 3'-deoxyguanosine copper zinc superoxide withalongolide n tetrahydronicotinamide adenine dinucleotide phosphate prostaglandin superoxide
organisms 8
multicellular animals humans human rodents homo heidelbergensis humans multicellular animals multicellular animals

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License: CC-BY-4.0 · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine