Integrated GNPS, semi-preparative HPLC, and network pharmacology reveal active ingredients and potential machenisms of Paeonia suffruticosa Andr. leaves in treating endometriosis with anxiety/depression

Tian YY, Yun-Yuan Tian, Fan MZ, Meng-Zhen Fan, Mingtao Fan, Hsin-Wen Huang, Xin-Wen Huang, Huang XW, Luo Q, Qian Luo, Yang Q, Qian Yang, Li Yao, Yao Li, Li Y, Lu YY, Yun-Yang Lu, Yunyang Lu, Siwang Wang, Si-Wang Wang, Wang SW
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2025 · vol. 1267 , pp. 124798 · doi:10.1016/j.jchromb.2025.124798 · PMID:40987078 · W4414303848
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Researchers identified active compounds and their mechanisms in Paeonia suffruticosa leaves for treating endometriosis with anxiety/depression using GNPS, HPLC, and network pharmacology.

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Abstract

Endometriosis (EMs) with anxiety/depression is a common comorbidity of EMs, yet effective treatments are still lacking. Leaves of Paeonia suffruticosa Andr. (PSL) have potential therapeutic effects on EMs and their associated psychiatric disorders. In this study, 57 chemical compounds were identified using Global Natural Products Social Molecular Networking (GNPS) and semi-preparative HPLC. Network pharmacology analysis revealed that these compounds shared 68 common targets with the disease, primarily enriched in the PI3K/AKT signaling pathway. Protein-protein interaction analysis identified TNF, IL-6, ESR1, AKT1, and TP53 as core targets. Molecular docking confirmed that apigenin, quercetin, kaempferol, luteolin, and isorhamnetin exhibited strong binding affinities with these core targets. In conclusion, PSL may exert beneficial effects in treating EMs with anxiety/depression by modulating the PI3K/AKT signaling pathway through key targets including TNF, IL-6, ESR1, AKT1, and TP53.

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Condition tags

endometriosis

MeSH descriptors

Anxiety Anxiety Anxiety Anxiety Anxiety Anxiety Anxiety Anxiety Anxiety Anxiety Anxiety Anxiety Anxiety Anxiety Anxiety Anxiety Anxiety Anxiety Anxiety Anxiety

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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