Expression of phosphoinositide-specific phospholipase C enzymes in normal endometrium and in endometriosis

Vincenza Rita Lo Vasco, Martina Leopizzi, Caterina Chiappetta, Businaro R, Rita Businaro, Patrizia Polonia, Polonia P, Carlo Della Rocca, Pietro Litta, Litta P
Fertility and sterility · 2012 · vol. 98(2) , pp. 410–414 · doi:10.1016/j.fertnstert.2012.04.020 · PMID:22608312 · W2164528059
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This study investigated the expression patterns of phosphoinositide-specific phospholipase C enzymes within normal endometrial tissue and compared these to their expression in endometriosis.

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Abstract

ObjectiveTo delineate the panel of expression of phosphoinositide-specific phospholipase C (PI-PLC) signaling enzymes in normal endometrium and in endometriosis.DesignClinical/experimental study.SettingUniversity.Patient(s)Healthy donor woman and endometriosis-affected woman.Intervention(s)Normal endometrium and endometriosis surgical biopsies were analyzed using gene expression analyses methodology (reverse transcriptase-polymerase chain reaction [PCR], bioanalyses).Main outcome measure(s)Gene expression (messenger RNA concentration) measures of 12 PI-PLC enzymes: PI-PLC β1, PI-PLC β2, PI-PLC β3, PI-PLC β4, PI-PLC γ1, PI-PLC γ2, PI-PLC δ1, PI-PLC δ3, PI-PLC δ4, PI-PLC ε, PI-PLC η1, and PI-PLC η2.Result(s)PI-PLC β1, PI-PLC β3, PI-PLC δ1, and PI-PLC δ3 enzymes were detected, although differently expressed in normal and endometriosis tissues.Conclusion(s)The involvement of PI-PLC enzymes in inflammation and the consistency of susceptible endometriosis loci with PI-PLC genes mapping corroborate the hypothesis that PI signaling might be involved in the pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Gene Expression Regulation, Enzymologic Phosphoinositide Phospholipase C Adult Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Humans Phosphoinositide Phospholipase C Phosphoinositide Phospholipase C

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