Therapeutic Effects of VEGF Gene-Transfected BMSCs Transplantation on Thin Endometrium in the Rat Model

Jing Zhao, Yan Yi, Xi Huang, Lunquan Sun, Yanping Li
In: Stem Cells International · 2018 · vol. 2018 , pp. 1–10 · doi:10.1155/2018/3069741 · PMID:30510583 · W2899288906
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Transplantation of VEGF gene-transfected BMSCs improved endometrial thickness, morphology, receptivity markers, and embryo implantation efficiency in a rat model of thin endometrium compared to BMSCs alone.

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Abstract

OBJECTIVE: Bone mesenchymal stem cells (BMSCs) transplantation has a therapeutic effect on the thin endometrium in animal researches and clinical trials. The present study aims at assessing whether transplantation of VEGF-transfected BMSCs (VEGF-BMSCs) have a better therapeutic effect on endometrial regeneration and endometrial receptivity compared with BMSCs therapy alone. METHODS: Sprague-Dawley (SD) rats were used in the study. Thin endometrium model was established with 95% ethanol injection into uterine. VEGF-BMSCs or BMSCs was transplanted via tail vein IV injection. Endometrial thickness, morphology, and pinopodes were assessed by hematoxylin and eosin (HE) staining and scanning electron microscope (SEM). The proteins and mRNAs expressions of markers for endometrial cells and endometrial receptivity were measured after treatment. The fertility testing was done to assess the embryo implantation efficiency. RESULTS: was significantly upregulated compared with those of the control group and BMSC group both 4 and 8 days after treatment. The pinopodes were developed better in the VEGF-BMSCs group and the sham operation group compared with BMSCs group and the control group. The number of embryo implantation is largest in the sham operation group, followed by VEGF-BMSCs group, BMSCs group, and the control group. CONCLUSIONS: Transplantation of VEGF gene-transfected BMSCs may be a better therapeutic treatment for thin endometrium than stem cell therapy alone.

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organisms 39
rodents zitter rats rodents human rodents rodents multicellular animals zitter rats human rattus sp. zitter rats rattus sp. rattus sp. rattus sp. rattus sp. rattus sp. naine d'afrique de l'ouest zitter rats rabbits rabbits zitter rats zitter rats rattus sp. human zitter rats rattus sp. rattus sp. human linopodes mammals zitter rats linopodes rodents zitter rats rattus sp. human human noordeloos 2009062 rodents
chemicals 32
ethanol haematoxylin estrogen clopidogrel pentoxifylline water ethanol chloral hydrate nitrogen haematoxylin xylene ethanol water haematoxylin xylene formaldehyde xylene ethanol water hydrogen haematoxylin polyurethane polymer tris water glutaraldehyde osmium acetone water acetone carbon dioxide mannoprotein progesterone

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