Gynaecological Considerations in PoTS
PoTS in women is associated with gynecological issues like menstrual irregularities, pelvic pain, and prolapse, influenced by hormones and linked to EDS and MCAS.
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This chapter reviews reported gynecological effects of postural orthostatic tachycardia syndrome (PoTS/POTS), relating them to hypermobile Ehlers-Danlos syndrome (hEDS), mast cell activation syndrome, histamine intolerance, and the timing effects of female sex hormones and the menstrual cycle on cardiovascular and inflammatory episodes. It describes that women with PoTS have more menstrual irregularities and pelvic pain, as well as vulval inflammatory and pain conditions, and notes a higher prevalence of vaginal prolapse that is harder to treat when hypermobile EDS is present. The chapter discusses potential management approaches such as menstrual cycle suppression with hormones and use of histamine receptor blockers or mast cell stabilising medications, while the main caveat is that the text is an explanatory clinical/thematic overview rather than a single primary study. Relevance to endometriosis: endometriosis is not directly discussed, but the chapter includes a mechanistic preclinical study where the mast cell stabilizer ketotifen reduces hyperalgesia in a rodent model of surgically induced endometriosis, alongside gynecologic considerations for PoTS.
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Cites (3)
- <p>Mast cell stabilizer ketotifen reduces hyperalgesia in a rodent model of surgically induced endometriosis</p> 2019
- Gynecologic symptoms and the influence on reproductive life in 386 women with hypermobility type ehlers-danlos syndrome: a cohort study 2016
- Gynecological associated disorders and management 2019
References (49)
- Gynecological associated disorders and management via openalex
- Gynecologic symptoms and the influence on reproductive life in 386 women with hypermobility type ehlers-danlos syndrome: a cohort study via openalex
- <p>Mast cell stabilizer ketotifen reduces hyperalgesia in a rodent model of surgically induced endometriosis</p> via openalex
- W1854421037 via openalex
- W1967905949 via openalex
- W1969255443 via openalex
- W1969663478 via openalex
- W1998079368 via openalex
- W2004165538 via openalex
- W2006128802 via openalex
- W2010652546 via openalex
- W2033388083 via openalex
- W2036355013 via openalex
- W2041020295 via openalex
- W2046110768 via openalex
- W2047203711 via openalex
- W2048227541 via openalex
- W2052329642 via openalex
- W2052352944 via openalex
- W2104432151 via openalex
- W2113993848 via openalex
- W2116432610 via openalex
- W2155549071 via openalex
- W2156409659 via openalex
- W2158298420 via openalex
- W2163081574 via openalex
- W2254430397 via openalex
- W2292610777 via openalex
- W2331336536 via openalex
- W2336875709 via openalex
- W2338172465 via openalex
- W2418670973 via openalex
- W2502494821 via openalex
- W2534013721 via openalex
- W2587456375 via openalex
- W2587587938 via openalex
- W2626230812 via openalex
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- W2940419140 via openalex
- W2965435012 via openalex
- W3165708572 via openalex
- W4230839666 via openalex
- W4242560816 via openalex
- W303114377 via openalex
- W6666142996 via openalex
- W1561510110 via openalex
- W1595142782 via openalex
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