Gynaecological Considerations in PoTS

In: Postural Tachycardia Syndrome · 2020 · pp. 141–152 · doi:10.1007/978-3-030-54165-1_18 · W3094130993
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AI-generated summary by claude@2026-06+body, 2026-06-13

PoTS in women is associated with gynecological issues like menstrual irregularities, pelvic pain, and prolapse, influenced by hormones and linked to EDS and MCAS.

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This chapter reviews reported gynecological effects of postural orthostatic tachycardia syndrome (PoTS/POTS), relating them to hypermobile Ehlers-Danlos syndrome (hEDS), mast cell activation syndrome, histamine intolerance, and the timing effects of female sex hormones and the menstrual cycle on cardiovascular and inflammatory episodes. It describes that women with PoTS have more menstrual irregularities and pelvic pain, as well as vulval inflammatory and pain conditions, and notes a higher prevalence of vaginal prolapse that is harder to treat when hypermobile EDS is present. The chapter discusses potential management approaches such as menstrual cycle suppression with hormones and use of histamine receptor blockers or mast cell stabilising medications, while the main caveat is that the text is an explanatory clinical/thematic overview rather than a single primary study. Relevance to endometriosis: endometriosis is not directly discussed, but the chapter includes a mechanistic preclinical study where the mast cell stabilizer ketotifen reduces hyperalgesia in a rodent model of surgically induced endometriosis, alongside gynecologic considerations for PoTS.

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Abstract

The gynaecological impact of PoTS is associated with hypermobile Ehlers Danlos syndrome (hEDS), mast cell activation syndrome (MCAS), histamine intolerance and the influence of female sex hormones. The menstrual cycle plays a key role in changing the cardiovascular environment as well producing inflammatory episodes during menstruation. Women with PoTS have more menstrual irregularities and also suffer from pelvic pain, and vulval inflammatory and pain conditions. Treatment can involve suppressing the menstrual cycle hormonally or using type 1 and 2 histamine receptor blockers or mast cell stabilising medications. There is a higher prevalence of vaginal prolapse which is more challenging to treat due to the association with hypermobile EDS. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

References

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Springer, Cham. https://doi.org/10.1007/978-3-030-54165-1_18 Download citation DOI: https://doi.org/10.1007/978-3-030-54165-1_18 Published: Publisher Name: Springer, Cham Print ISBN: 978-3-030-54164-4 Online ISBN: 978-3-030-54165-1 eBook Packages: MedicineMedicine (R0)

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