EXPRESSION OF CONCERN: Melatonin Protects Against Endometriosis via Regulation of Matrix Metalloproteinase-3 and an Apoptotic Pathway

Journal of pineal research · 2026 · vol. 78(2) , pp. e70126 · doi:10.1111/jpi.70126 · PMID:41769762
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⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

Concerns about the resemblance of Figure 6 images to small intestine tissue, rather than uterine tissue, have led to an Expression of Concern regarding this study on melatonin's protective effects against endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-13 · read from full text ⓘ

The Journal of Pineal Research has issued an Expression of Concern for an article titled “Melatonin Protects Against Endometriosis via Regulation of Matrix Metalloproteinase-3 and an Apoptotic Pathway,” reporting findings from a surgically induced mouse endometriosis model. The journal states that third parties raised concerns because elements in Figure 6(A–C) closely resembled small intestine rather than endometrial (uterine) tissue in mice, and the authors could not retrieve the underlying raw image data due to the time elapsed since publication. Although the authors provided a clarification arguing the images represent uterine tissue based on morphological and cycle-related features, the possibility that a different tissue type was used cannot be fully ruled out. This paper is centrally about endometriosis — it is an Expression of Concern for a study specifically proposing melatonin regulation of matrix metalloproteinase-3 and apoptotic pathways in an endometriosis mouse model.

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Abstract

S. Paul, P. Bhattacharya, P. D. Mahapatra, and S. Swarnakar, "Melatonin Protects Against Endometriosis via Regulation of Matrix Metalloproteinase-3 and an Apoptotic Pathway," Journal of Pineal Research 49, no. 2 (2010): 156-168, https://doi.org/10.1111/j.1600-079X.2010.00780.x. This Expression of Concern is for the above article, published online on 02 August 2010 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Gianluca Tosini; and John Wiley & Sons Ltd. The Expression of Concern has been agreed due to concerns raised by third parties. Specifically, the features of the sections presented in Figure 6 (A), (B), and (C) were found to closely resemble those of small intestine rather than endometrial (uterine) tissue in mice. Due to the time elapsed since publication, the authors were unable to retrieve the raw data underlying the images. Despite the authors highlighting several features in their clarification to support that the images represent uterine tissue from a surgically induced mouse endometriosis model-such as morphological details of uterine glands, stroma, blood vessels, and expected cycle-related changes-they also acknowledge that the possibility of having reported a different tissue type cannot be fully ruled out. Therefore, the journal has decided to issue an Expression of Concern to inform and alert the readers.
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EXPRESSION OF CONCERN: Melatonin Protects Against Endometriosis via Regulation of Matrix Metalloproteinase-3 and an Apoptotic Pathway Abstract EXPRESSION OF CONCERN: S. Paul, P. Bhattacharya, P. D. Mahapatra, and S. Swarnakar, “Melatonin Protects Against Endometriosis via Regulation of Matrix Metalloproteinase-3 and an Apoptotic Pathway,” Journal of Pineal Research 49, no. 2 (2010): 156–168, https://doi.org/10.1111/j.1600-079X.2010.00780.x. This Expression of Concern is for the above article, published online on 02 August 2010 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Gianluca Tosini; and John Wiley & Sons Ltd. The Expression of Concern has been agreed due to concerns raised by third parties. Specifically, the features of the sections presented in Figure 6 (A), (B), and (C) were found to closely resemble those of small intestine rather than endometrial (uterine) tissue in mice. Due to the time elapsed since publication, the authors were unable to retrieve the raw data underlying the images. Despite the authors highlighting several features in their clarification to support that the images represent uterine tissue from a surgically induced mouse endometriosis model—such as morphological details of uterine glands, stroma, blood vessels, and expected cycle-related changes—they also acknowledge that the possibility of having reported a different tissue type cannot be fully ruled out. Therefore, the journal has decided to issue an Expression of Concern to inform and alert the readers.

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Condition tags

endometriosis

MeSH descriptors

Apoptosis Apoptosis Apoptosis Apoptosis Apoptosis Apoptosis Apoptosis Apoptosis Apoptosis Apoptosis Apoptosis Apoptosis Apoptosis Apoptosis Apoptosis Apoptosis Apoptosis Apoptosis Apoptosis Apoptosis

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europepmc
last seen: 2026-07-26T06:08:39.051465+00:00
pubmed
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