From live birth to live birth: a strong correlation between the outcomes of first and second frozen-thawed euploid blastocyst transfers from sibling oocytes.

Purpose To investigate any correlation between the outcomes of the first euploid frozen-thawed blastocyst embryo transfer (FBT) and the subsequent euploid FBT derived from sibling oocytes.

This retrospective study analyzed data from 1051 women who underwent preimplantation genetic testing for aneuploidy and had a euploid FBT. Of these patients, 159 underwent a second transfer. The primary outcome was the live birth rate.

Overall, 159 women who underwent a second euploid FBT were categorized into two subgroups depending on the implantation success of the first FBT. Of these patients, 94 (59.1%) belonged to the nonclinical group, signifying a negative result or a biochemical pregnancy. The remaining 65 (40.9%) patients belonged to the clinical group, indicating either a miscarriage or a live birth. In the binary logistic regression analysis, the live birth outcome during the first euploid FBT was a statistically significant and independent predictor of live birth in the subsequent FBT [odds ratio 4.14, 95% confidence interval (1.184–14.531), p < 0.026). Miscarriages, including those that occurred before intracytoplasmic sperm injection and in the first euploid FBT, reduced the live birth rate by approximately 34% (p < 0.027). No significant difference in the miscarriage rate was found between the two subgroups (19.2% (10/52) vs. 25.4% (14/55), p = 0.38).

The live birth outcome of the second euploid FBT is mainly determined by the live birth outcome of the first. Miscarriages that occurred before in vitro fertilization negatively affect the live birth outcome. Similar content being viewed by others Data availability Our dataset can be accessed from the link: https://data.mendeley.com/datasets/sfd8vskc73/1

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The authors would like to express their gratitude to all clinical and scientific staff at the Bahceci IVF Group for their assistance with data extraction. Author information Authors and Affiliations Contributions The study was designed and written by Niyazi Emre Turgut and Fazilet Kübra Boynukalin. All analysis variables were evaluated and completed by Niyazi Emre Turgut and Meral Gultomruk. The statistical analysis was undertaken by Zalihe Yarkiner. The final version of the study was approved to be submitted by Remzi Abali and Mustafa Bahceci. All authors have agreed to the final version of the manuscript. Corresponding author Ethics declarations Ethics approval Institutional review board approval was obtained to evaluate the retrospective data (Application no.:102). Competing interests The authors declare no competing interests. Additional information Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Rights and permissions Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. About this article Cite this article Turgut, N.E., Boynukalin, F.K., Gultomruk, M. et al. From live birth to live birth: a strong correlation between the outcomes of first and second frozen-thawed euploid blastocyst transfers from sibling oocytes. J Assist Reprod Genet 42, 193–200 (2025). https://doi.org/10.1007/s10815-024-03329-w Received: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s10815-024-03329-w