Endometrial effects of three doses of trimegestone, a new orally active progestogen, on the postmenopausal endometrium

David J. Ross, D Ross, V Godfree, VA Godfree, A Cooper, Alison Cooper, J. Pryse‐Davies, J Pryse-Davies, Malcolm Whitehead, M I Whitehead
Maturitas · 1997 · vol. 28(1) , pp. 83–88 · doi:10.1016/s0378-5122(97)00058-3 · PMID:9391999 · W2143643337
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This study found that oral trimegestone combined with estradiol induced secretory transformation of the postmenopausal endometrium across all tested doses, indicating its effectiveness for endometrial protection.

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Abstract

OBJECTIVE: To study the effects of oral trimegestone on endometrial histology and vaginal bleeding when given in combination with oral 17-beta-oestradiol. METHODS: This was a prospective, randomised, double-blind, parallel groups, pilot comparative study. Thirty-eight healthy postmenopausal women with normal endometrial histology were given oral 17-beta-oestradiol, 2 mg/day for three continuous cycles of 28 days, plus oral trimegestone, 0.10, 0.25 or 0.50 mg/day from day 15 to day 28 of each cycle. A Vabra biopsy was performed late in the oestradiol/trimegestone phase of cycle 3 and examined for histological evidence of secretory transformation of the endometrium. Characteristics of vaginal bleeding were recorded on a daily basis. RESULTS: Thirty-seven women completed the study, of whom 31 yielded adequate tissue for histological assessment. All showed secretory transformation of the endometrium. Bleeding was of earlier onset and longer duration with the lowest dose of trimegestone. CONCLUSIONS: Trimegestone is a highly effective oral progestogen for endometrial protection, all doses inducing secretory endometrial transformation. Although bleeding patterns suggest a weaker effect of the lowest dose used, the minimum effective dose for endometrial protection has still to be determined and may be lower than those used in this study.

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MeSH descriptors

Endometrium Estrogen Replacement Therapy Postmenopause Promegestone Administration, Oral Dose-Response Relationship, Drug Double-Blind Method Endometrium Estrogen Replacement Therapy Female Humans Menstrual Cycle Menstrual Cycle Middle Aged Pilot Projects Postmenopause Promegestone Promegestone Promegestone Promegestone

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