Endometriosis and infertility: our experience over five years

D Federici, Duccio Federici, E Conti, W Costantini, D Bucchino, Rosario Fornaro, R Fornaro, M Boerci, A Uglietti, Anna Uglietti, F Polvani
Human Reproduction · 1988 · vol. 3(1) , pp. 109–111 · doi:10.1093/oxfordjournals.humrep.a136639 · PMID:3350929 · W1953694622
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Over five years, 163 infertile patients were diagnosed with endometriosis, and conception rates varied after Danazol therapy, conservative surgery, or expectant management for minimal disease.

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Abstract

During a 5-year period, we diagnosed endometriosis by laparoscopy in 163 infertile patients (7.9% of the infertile population). Seventy-one women presented with minimal endometriosis, 32 women a mild form, 38 women a moderate form and 22 women a severe form. Only 40 patients (24.5%) were found to have endometriosis as the only abnormality in a complete fertility work-up. One hundred and twenty patients were treated with Danazol (600 mg daily for 4-6 months) and 33 of them conceived (27.5%). Twenty-eight patients received conservative surgical treatment associated with Danazol therapy and 11 of them conceived (39.2%). In the 15 patients with minimal endometriosis, who had no therapy but expectant management, there were two conceptions within one year (13.3%). The anticipation of minimal disease in patients with endometriosis as the only abnormality produced about the same results as achieved by active treatment (pregnancy rate of 33.3% after expectant management and 36.3% after treatment). These results suggest that minimal endometriosis can be anticipated only when there are no co-existing factors of infertility.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Adult Combined Modality Therapy Danazol Danazol Endometriosis Endometriosis Endometriosis Female Follow-Up Studies Humans Infertility, Female Pregnancy Pregnancy Outcome

Citation neighborhood

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