Endometriosis Tissues Identifies Genes Related to Organogenesis

Maria Teresa Piccolo, Aldo Donizetti, Rosa Viceconte, Maria A. Spyrou, Raffaele Calogero, Alfonso Baldi, Pietro G. Signorile
2013 · W2311270553
article OA: closed CC0 Metadata only
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Abstract

Endometriosis is a common benign pathology, characterised by the presence of endometrial tissue outside the endometrial cavity with a prevalence of 10–15% in reproductive-aged women. The pathogenesis is not completely understood, and several theories have been proposed to explain the aetiology. Our group has recently described the presence of ectopic endometrium in a consistent number of human female foetuses analysed by autopsy, reinforcing the hypothesis that endometriosis may be generated by defects during the organogenesis of the female reproductive trait. Herein, in order to identify, at molecular level, changes involved in the disease, we compared the transcriptional profiling of ectopic endometrium with the corresponding eutopic one. Statistical analyses lead us to identify some genes specifically deregulated in the ectopic endometrium, that are involved in gonad developmental process or in wound healing process. Among them, we identified BMP4 and GREM1. BMP4 was never associated before to endometriosis and is involved in the

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endometriosis

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