Preliminary research of the detection of aromatase cytochrome P450 for endometriosis in infertility

Objective To study the role of aromatase cytochrom P450 in the pathogenesis of endometriosis and the practicability of it serving as a diagnostic marker for endometriosis in infertility. Methods The expression of aromatase cytochrom P450 in eutopic endometrium of endometriosis and non-endometriosis of infertility was determined by immunohistochemical assay.Results There was a significant difference in the expression of aromatase cytochrom P450 between eutopic endometrium of endometriosis and non-endometriosis.There was no difference between proliferative and secretory endometrium of endometriosis.No correlation was observed between the expression of aromatase cytochrome P450 and AFS stage of endometriosis.As a diagnostic test for endometriosis by measuring aromatase cytochrome P450 in eutopic endometrium of endometriosis in infertility,the sensitivity,specificity,positive predictive value and negative predictive value were 90%,86%,86.5% and 89.6%.Conclusion The expression of aromatase cytochrom P450 in endometrium may play an important role in pathogenesis of endometriosis and can be used as a diagnostic test for endometriosis in infertility.