FSH RECEPTOR AND FSH BETA CHAIN POLYMORPHISM INVOLVEMENT IN INFERTILITY AND ENDOMETRIOSIS DISEASE

A Tanase, D Nemescu, R Popescu, B F Toma, R D Matasariu, M Onofriescu
Acta endocrinologica (Bucharest, Romania : 2005) · 2020 · doi:10.4183/aeb.2020.142 · PMID:33029229 · PMC7535885
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FSH receptor and FSH beta chain polymorphisms were not associated with endometriosis severity in Romanian women but may be linked to female infertility, requiring further study.

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The study evaluated whether follicle-stimulating hormone (FSH) receptor polymorphism (c.-29G>A) and FSH beta chain polymorphism (c.-280G>T) are associated with endometriosis and its severity in Romanian women, using peripheral-blood genomic DNA. RFLP analysis was performed in 44 women with endometriosis and 34 controls, comparing genotype frequencies between cases and controls and across minimal/mild versus moderate/severe endometriosis groups. No significant differences were found for FSH receptor polymorphism between patients and controls, and no significant associations were observed between either polymorphism and endometriosis severity. The paper notes that these polymorphisms do not appear to influence severity, but they could relate to female infertility, requiring further study; This paper is centrally about endometriosis — it tests FSH receptor and FSH beta-chain polymorphisms for association with endometriosis presence and severity in Romanian women.

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Abstract

OBJECTIVES: The purpose of this study was to evaluate the association between the follicle-stimulating hormone (FSH) receptor (c.-29G>A) and FSH beta chain (c.-280G>T) polymorphisms and endometriosis in Romanian women. MATERIAL AND METHODS: We performed the polymorphic analysis of the FSH receptor gene and FSH beta chain in 44 patients with endometriosis and 34 controls. Genomic DNA was obtained from peripheral blood and polymorphisms were investigated using restriction fragment length polymorphism analysis (RFLP). RESULTS: There were no significant differences in genotype frequencies of FSH receptor gene between endometriosis patients and controls. For the heterozygous type of the FSH receptor polymorphism (c.-29G>A) we did not find a significant difference in its frequency between patients with minimal/mild and moderate/severe endometriosis (p = 0.136). Also, the FSH beta chain (c.-280G> T) polymorphism frequency was not significantly associated with the severity of endometriosis (p = 0.966). CONCLUSIONS: FSH receptor and FSH beta chain polymorphisms do not seem to influence the severity of endometriosis, but they could be correlated with female infertility (primary or secondary), therefore further studies are required to debate this topic.
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Material

and methods. We performed the polymorphic analysis of the FSH receptor gene and FSH beta chain in 44 patients with endometriosis and 34 controls. Genomic DNA was obtained from peripheral blood and polymorphisms were investigated using restriction fragment length polymorphism analysis (RFLP). Results. There were no significant differences in genotype frequencies of FSH receptor gene between endometriosis patients and controls. For the heterozygous type of the FSH receptor polymorphism (c.-29G>A) we did not find a significant difference in its frequency between patients with minimal/mild and moderate/severe endometriosis (p = 0.136). Also, the FSH beta chain (c.- 280G> T) polymorphism frequency was not significantly associated with the severity of endometriosis (p = 0.966). Conclusions. FSH receptor and FSH beta chain polymorphisms do not seem to influence the severity of endometriosis, but they could be correlated with female infertility (primary or secondary), therefore further studies are required to debate this topic.

Keywords

FSH receptor, LH receptor, FSH receptor, endometriosis, infertility, polymorphism. Correspondence: Dragos Nemescu MD, “Cuza Voda” Hospital, Maternal Fetal Medicine Department, Cuza Voda 34, Iasi, 700038, Romania, E-mail: [email protected]

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endometriosisinfertility

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