{"paper_id":"ca36ef67-17dd-43bf-bb2c-84427bccd8c7","body_text":"- Login\n- Register\n- Home/Current Issue\n- About the journal\n- Editorial board\n- Online submission\n- Instructions for authors\n- Subscriptions\n- Foundation Acta Endocrinologica\n- Archive\n- Contact\nRomanian Academy\nThe Publishing House of the Romanian Academy\nACTA ENDOCRINOLOGICA (BUC)\nThe International Journal of Romanian Society of Endocrinology / Registered in 1938in Web of Science Master Journal List\nActa Endocrinologica(Bucharest) is live in PubMed Central\nJournal Impact Factor - click here.\nThis Article\nServices\nGoogle Scholar\nPubMed\nActa Endocrinologica (Buc)\nTanase A, Nemescu D, Popescu R, Toma BF, Matasariu RD, Onofriescu M\nFSH Receptor and FSH Beta Chain Polymorphism Involvement in Infertility and Endometriosis Disease\nActa Endo (Buc) 2020, 16 (2): 142-147doi: 10.4183/aeb.2020.142\nObjectives. The purpose of this study was to\nevaluate the association between the follicle-stimulating\nhormone (FSH) receptor (c.-29G>A) and FSH beta chain (c.-\n280G>T) polymorphisms and endometriosis in Romanian\nwomen.\nMaterial and methods. We performed the\npolymorphic analysis of the FSH receptor gene and FSH\nbeta chain in 44 patients with endometriosis and 34 controls.\nGenomic DNA was obtained from peripheral blood and\npolymorphisms were investigated using restriction fragment\nlength polymorphism analysis (RFLP).\nResults. There were no significant differences\nin genotype frequencies of FSH receptor gene between\nendometriosis patients and controls. For the heterozygous\ntype of the FSH receptor polymorphism (c.-29G>A)\nwe did not find a significant difference in its frequency\nbetween patients with minimal/mild and moderate/severe\nendometriosis (p = 0.136). Also, the FSH beta chain (c.-\n280G> T) polymorphism frequency was not significantly\nassociated with the severity of endometriosis (p = 0.966).\nConclusions. FSH receptor and FSH beta chain\npolymorphisms do not seem to influence the severity of\nendometriosis, but they could be correlated with female\ninfertility (primary or secondary), therefore further studies\nare required to debate this topic.\nKeywords: FSH receptor, LH receptor, FSH\nreceptor, endometriosis, infertility, polymorphism.\nCorrespondence: Dragos Nemescu MD, “Cuza Voda” Hospital, Maternal Fetal Medicine Department, Cuza Voda 34, Iasi, 700038,\nRomania, E-mail: dragos.nemescu@umfiasi.ro","source_license":"public-domain-us","license_restricted":false}