Association between severity of pain, perceived stress and vagally-mediated heart rate variability in women with endometriosis

De França Moreira, Marcelo, Olga Lucia Gamboa, Olga Lucía Gamboa, Gamboa OL, Marco Aurélio Pinho Oliveira, Marco Aurelio Pinho Oliveira, Pinho Oliveira MA
Women & health · 2021 · vol. 61(10) , pp. 937–946 · doi:10.1080/03630242.2021.1993423 · PMID:34719338 · W3208245125
Observational OA: closed CC0 ⤵ 6 in-corpus citations
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This study found that lower vagally-mediated heart rate variability and higher perceived stress were associated with increased pain severity and unpleasantness in women with endometriosis.

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Abstract

Chronic pelvic pain is the main symptom in women with endometriosis. Evidence suggests that psychological stress and autonomic regulation contribute to symptoms and pathophysiological modulation. We investigated the relationship between endometriosis-related pain severity, perceived stress, and autonomic balance in a sample of 81 women suffering chronic pelvic pain with deep endometriosis. Perceived stress and pelvic pain symptoms were assessed using the 10-item version of the Perceived Stress Scale (PSS-10) and the Numeric Pain Rating Scale (NPRS), respectively. Autonomic nervous system regulation was evaluated using vagally mediated components of the heart rate variability (vmHRV). Our results showed that pain unpleasantness and perceived stress were positively correlated, and women with mood disorders had higher perceived stress. The women with low resting vmHRV experience more intense pelvic pain, pain unpleasantness, and a higher number of severe endometriosis-related pain descriptors. The positive association between perceived stress, mood disorder, and pain unpleasantness demonstrates the additive effect between these aversive experiences. The inverse association between parasympathetic tone and pain suggests contributions of the Descending Inhibitory Pain pathway efficiency to symptom severity in women with endometriosis.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Endometriosis Endometriosis Endometriosis Female Female Heart Rate Heart Rate Humans Humans Pain Measurement Pain Measurement Pelvic Pain Pelvic Pain Pelvic Pain Stress, Psychological Stress, Psychological

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (36)

Cited by (7)

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europepmc
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License: CC0 · commercial use OK