Correlations between periovulatory serum and follicular fluid CA-125 and granulosa cell hormones after controlled ovarian hyperstimulation

Vishakh Saraf; Margaret O’Neill; Anthony Riccioli; Pedro Daniel Penha; Michael Femi Obasaju; John B. Josimovich

doi:10.1016/0301-2115(95)02168-7

Correlations between periovulatory serum and follicular fluid CA-125 and granulosa cell hormones after controlled ovarian hyperstimulation

Vishakh Saraf, Margaret O’Neill, Anthony Riccioli, Pedro Daniel Penha, Michael Femi Obasaju, John B. Josimovich

In: European Journal of Obstetrics & Gynecology and Reproductive Biology · 1995 · vol. 62(1) , pp. 95–99 · doi:10.1016/0301-2115(95)02168-7 · PMID:7493717 · W2004627822

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This study investigated the relationship between CA-125 levels in serum and follicular fluid and granulosa cell hormones during controlled ovarian hyperstimulation.

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Abstract

ObjectiveTo determine the presence and concentration of CA-125 in periovulatory follicular fluid (FF) and serum after controlled ovarian hyperstimulation and to determine if the CA-125 in these two compartments could be related to granulosa cell markers such as inhibin or estradiol.Study designFifteen women undergoing controlled ovarian hyperstimulation for in-vitro fertilization-embryo transfer were studied. A transvaginal, ultrasound-guided follicular aspiration was performed. CA-125, inhibin, estradiol and FSH were measured in FF and serum. Pearson and Spearman's Rank Correlation tests were performed.ResultsCA-125 was measurable in 59% of follicles. Values ranged from undetectable to 3630 U/ml. Serum CA-125 ranged from undetectable to 126 U/ml. CA-125 and inhibin correlated negatively in FF and positively in serum.ConclusionCA-125 was present in significant but variable concentrations in 59% of periovulatory follicles. A negative correlation was noted between CA-125 and inhibin or estradiol in the FF and a positive correlation with serum inhibin. No correlations were noted to oocyte retrieval or fertilization.

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[1] Serum CA-125 antigen levels increase during menses 1987

[2] The CA 125 tumour-associated antigen: a review of the literature 1989