Correlation between serum levels of CA 125 and follicular loss after laparoscopic cystectomy in women with ovarian endometrioma

Mario Vicino, Resta L, Leonardo Resta, Scioscia M, Marco Scioscia, Andrea Marzullo, Ceci O, Oronzo Ceci, Stefano Bettocchi
Journal of Minimally Invasive Gynecology · 2007 · vol. 14(2) , pp. 223–227 · doi:10.1016/j.jmig.2006.10.002 · PMID:17368261 · W2157428450
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This study investigated the relationship between serum CA 125 levels and follicular loss following laparoscopic cystectomy in women diagnosed with ovarian endometrioma.

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Abstract

Study objectiveTo preoperatively predict follicular loss after laparoscopic cystectomy of ovarian endometriomas.DesignCase-control study. (Canadian Task Force classification II-2).SettingUniversity hospital.PatientsSeventy-six women with ovarian endometrioma and 41 patients with nonendometriotic ovarian cysts who underwent laparoscopy.InterventionsSonographic findings and serum levels of CA 125 and CA 19.9 were recorded.Measurements and main resultsConsidered parameters were compared with a histologic score, on the basis of the presence and morphologic features of follicles on the normal ovarian tissue adjacent to the cyst wall surgically removed. Serum levels of CA 125 and CA 19.9 were increased in patients with ovarian endometrioma (p <.001 and p <.01, respectively). Capsule wall thickness, presence of fibrosis, and follicles in the tissue surrounding the capsule were significantly increased in the study group (p <.01). CA 125 serum level was directly correlated to the histologic score (r = 0.46, p <.05) and to cyst diameter (r = 0.12, p = .01), whereas no correlation was found between CA 19.9 or cyst diameter and follicular score.ConclusionsOur data suggest that the ovarian tissue inadvertently removed along with the endometrioma wall by laparoscopic stripping is due to pericystic fibrosis. Serum levels of CA 125 represent a useful parameter to predict follicular loss before surgery.

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Condition tags

endometriosisendometrioma

MeSH descriptors

CA-125 Antigen Endometriosis Ovarian Cysts Ovarian Diseases Ovarian Follicle Adult CA-125 Antigen CA-19-9 Antigen CA-19-9 Antigen Case-Control Studies Endometriosis Endometriosis Female Humans Laparoscopy Laparoscopy Ovarian Cysts Ovarian Cysts Ovarian Diseases Ovarian Diseases

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