Biomaterials Empowering in New Era of Women's Healthcare System

Women’s health encompasses complex biological, reproductive, and gynecological challenges that require innovative solutions. This review systematically examines emerging biomaterials—such as hydrogels, nanoparticles, and polymers—and their transformative role in drug delivery, tissue repair, and regenerative medicine for conditions like breast cancer, endometriosis, and pregnancy-related disorders. A comprehensive literature search was conducted across PubMed, Scopus, Web of Science, ScienceDirect, and Google Scholar using defined MeSH terms and Boolean operators, covering studies published between 2000 and 2024. The novelty of this review lies in its integrated perspective on biomaterials and their application in women’s health, highlighting advances in smart drug delivery systems and regenerative strategies for female reproductive organs. Key insights include improved therapeutic precision, minimally invasive approaches, and enhanced biocompatibility of biomaterials. Additionally, the review explores policy initiatives and persistent challenges such as gender bias in research and limited access to cutting-edge treatments. Finally, the integration of artificial intelligence (AI) with biomaterials is discussed as an emerging approach to optimize design, personalize therapies, and improve clinical outcomes, signaling a new era of women-focused healthcare innovation. Graphical Abstract Similar content being viewed by others Data Availability All data and materials supporting this review are included within the manuscript; no additional datasets were generated or analysed.

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No funds, grants, or financial support were received for this research work. Author information Authors and Affiliations Contributions Parakh Basist: Study conception, design, supervision, and final approval of the manuscript; Bisma Jan: Data collection and literature compilation; Sradhanjali Mohapatra: Analysis and interpretation of results, revision; Debashish Paramanick: Study conception, design, and draft manuscript preparation. Swati Verma: Study conception, data collection and draft manuscript preparation, Swati Kaushik: Data collection and draft manuscript preparation. Corresponding author Ethics declarations Ethical Approval This study does not involve a clinical trial; it is a review-based research analysis and therefore trial registration and the CONSORT checklist are not applicable. Competing interest The authors declare no competing interests related to this review paper. Additional information Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Rights and permissions Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. About this article Cite this article Paramanick, D., Verma, S., Kaushik, S. et al. Biomaterials Empowering in New Era of Women's Healthcare System. Reprod. Sci. 33, 710–728 (2026). https://doi.org/10.1007/s43032-026-02066-y Received: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s43032-026-02066-y