Adenomyosis: Is It A Confounder Or An Innocent Companion In Patients With Endometrial Hyperplasia?

Fatma Nurgül Taşgöz, Nergis Kender Ertürk, Gülnur Tanrıverdi Kılıç, Gülay Gökçe
In: Research Square · 2021 · doi:10.21203/rs.3.rs-863575/v1 · W3201459102
preprint OA: green CC0
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This study evaluated adenomyosis's effect on discordant pathologic findings between endometrial sampling and hysterectomy specimens in patients diagnosed with endometrial hyperplasia.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This retrospective study evaluated whether co-existing adenomyosis affects how accurately endometrial hyperplasia (EH) is diagnosed by preoperative endometrial sampling compared with final pathology after hysterectomy, including 217 women who had EH on sampling and underwent hysterectomy within 3 months. Using grouped discordance definitions (overdiagnosis versus underdiagnosis) and multivariate logistic regression, the authors found overall concordance of 41.47%, with underdiagnosis associated with older age, higher BMI, postmenopausal status, and lower parity, and with adenomyosis occurring less often in the underdiagnosis group. In the multivariate analysis, adenomyosis was an independent risk factor for both increased overdiagnosis and underdiagnosis, with reported odds consistent with ~5.8-fold higher overdiagnosis and ~4.5-fold higher underdiagnosis. The study is limited as a preprint, retrospective single-center design relying on ultrasonography for myometrial lesion identification and excluding certain sampling approaches. Relevance to endometriosis: adenomyosis, a key entity in the endometriosis spectrum, is directly analyzed as a risk factor for discordance in pathology among patients with EH.

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adenomyosis

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