Action of danazol on 5′-nucleotidase activity of mouse peritoneal macrophages

V. V. Mitkin, N. I. Volkov, T.Ya. Pshenichnikova, Г. Т. Сухих
In: Bulletin of Experimental Biology and Medicine · 1992 · vol. 113(2) , pp. 231–233 · doi:10.1007/bf00791509 · W87183990
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This study investigated the effect of danazol on the 5′-nucleotidase activity of mouse peritoneal macrophages.

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This paper investigated how danazol affects 5′-nucleotidase activity in mouse peritoneal macrophages, using an experimental approach based on measuring enzyme activity after danazol exposure. The study’s main finding was that danazol altered 5′-nucleotidase activity in these macrophages. A key limitation is that the work is conducted in a mouse macrophage model, which constrains direct translation to human pelvic inflammatory or gynecologic disease mechanisms. Relevance to endometriosis: danazol is an anti-endometriosis medication, and this paper focuses on a danazol-related immunobiologic effect (macrophage enzyme activity) that could be relevant to mechanisms proposed for endometriosis, though endometriosis is not directly discussed in the provided text.

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Literature Cited V. V. Mit'kin, V. I. Kulakov, and G. T. Sukikh, Akush. Gin. G. T. Sukikh, N. I. Volkov, and I. D. Ionov, Diagnosis and Treatment of Childless Marriage [in Russian], Moscow (1988), pp. 122–127. Y. Ahn, W. Harrington, S. Simon, et al., New Engl. J. Med.,308, 1396 (1983). R. Barbieri and K. Ryan, Am. J. Obstet. Gynecol.,141, 453 (1981). D. Bartosik, Sem. Reprod. Endocrinol.,3, 329 (1985). A. El-Roeiy, W. Dmowsky, N. Gleicher, et al., Fertil. Steril.,50, 864 (1988). H. Fakih, B. Baggett, G. Holtz, et al., Fertil. Steril.,47, 213 (1987). N. Gleicher, A. El-Roeiy, E. Confino, et al., Obstet. Gynecol.,70, 115 (1987). R. Greenblatt, W. Dmowski, V. Mahesh, et al., Fertil. Steril.,22, 102 (1971). C. Grossman, Science,227, 257 (1985). A. Haney, J. Muscato, and J. Weinberg, Fertil. Steril.,35, 696 (1981). J. Hill, F. Haimovici, J. Politch, et al., Fertil. Steril.,47, 460 (1987). J. Hill, R. Barbieri, and D. Anderson, Fertil. Steril.,48, 414 (1987). R. Mylvaganam, Y. Ahn, W. Harrington, et al., Clin. Immunol. Immunopathol.,42, 281 (1987). Rights and permissions About this article Cite this article Mit'kin, V.V., Volkov, N.I., Pshenichnikova, T.Y. et al. Action of danazol on 5′-nucleotidase activity of mouse peritoneal macrophages. Bull Exp Biol Med 113, 231–233 (1992). https://doi.org/10.1007/BF00791509 Received: Issue date: DOI: https://doi.org/10.1007/BF00791509

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