Morphological and functional features of the endometrium in patients before and after ovary-sparing surgery for benign ovarian tumors

A.A. Solomatina, Л.М. Михалева, M.Yu. Tyumentseva, O.V. Bratchikova, I.Z. Khamzin, E.A. Tumasyan, A.I. Gashimova, P.D. Ismayilova
In: Voprosy ginekologii, akušerstva i perinatologii · 2022 · vol. 21(3) , pp. 45–52 · doi:10.20953/1726-1678-2022-3-45-52 · W4313318906
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study assessed endometrial morphology and function using 2D and 3D ultrasound in patients with benign ovarian tumors before and after ovary-sparing surgery, finding endometrial dysfunction more pronounced in those with diminished ovarian reserve.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

This study evaluated morphological and functional endometrial features before and 6–12 months after ovary-sparing surgery for benign ovarian tumors, using 2D and 3D ultrasound in 145 reproductive-age patients stratified by ovarian reserve (AMH <1.1 ng/mL vs normal). It found that patients with diminished ovarian reserve had endometrial dysfunction both pre- and postoperatively, while there was a trend toward improvement across measured endometrial thickness, pattern, and vascular visualization/volumetric blood flow after 12 months; in patients with normal ovarian reserve, baseline endometrial parameters were similar to the general population but postoperative abnormalities were more persistent. The authors conclude that 3D ultrasound objectively characterizes endometrial morphological and functional changes and can identify markers of endometrial dysfunction, with the main limitation being reliance on single-phase (mid-secretory) ultrasound assessments at specified timepoints. Relevance to endometriosis: the paper uses the concept of “endometriopathy” linking ovarian status and endometrial receptivity, but it does not specifically discuss endometriosis or adenomyosis mechanisms or cohorts.

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Abstract

Benign ovarian tumors (BOT) have a significant impact on fertility and are associated with infertility, which, in turn, relates to endometrial receptivity and depends on the ovarian status, forming the so-called endometriopathy. Objective. To study the morphological and functional features of the endometrium in patients of reproductive age before and after ovary-sparing surgery for BOT according to 2D and 3D ultrasounds. Patients and methods. The study included 145 patients who underwent surgery for BOT. Patients were divided into two groups. Group 1 included 75 patients with diminished ovarian reserve (OR), group 2 included 70 patients with normal OR. Diminished OR was defined as serum Anti-Müllerian hormone (AMH) level <1.1 ng/mL. Pelvic ultrasound (US) was performed in the mid-secretory phase before and 6–12 months after surgery. We measured endometrial thickness, endometrial pattern, visualization of basal and spiral arteries by 2D ultrasound, volume and volumetric blood flow in the endometrial and subendometrial regions by 3D ultrasound. Results. The analysis revealed endometrial dysfunction in patients with diminished OR before and after surgery, however there was a trend towards improvement in all the examined parameters after 12 months. In patients with normal OR before surgery, endometrial parameters did not differ from the population, but more persistent abnormalities were noted in the postoperative period. Conclusion. The 3D ultrasound technique provides an objective assessment of morphological and functional features of the endometrium and allows to identify markers of endometrial dysfunction. Key words: benign ovarian tumors, volumetric blood flow, ovarian reserve, 3D ultrasound, endometrium
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Morphological and functional features of the endometrium in patients before and after ovary-sparing surgery for benign ovarian tumors Antonina A. Solomatina / Lyudmila M. Mikhaleva / Marina Yu. Tyumentseva / Olga V. Bratchikova / Ildar Z. Khamzin / Elizaveta A. Tumasyan / Aysel I. Gashimova / Parvana D. Ismayilova / Benign ovarian tumors (BOT) have a significant impact on fertility and are associated with infertility, which, in turn, relates to endometrial receptivity and depends on the ovarian status, forming the so-called endometriopathy. Objective. To study the morphological and functional features of the endometrium in patients of reproductive age before and after ovary-sparing surgery for BOT according to 2D and 3D ultrasounds. Patients and methods. The study included 145 patients who underwent surgery for BOT. Patients were divided into two groups. Group 1 included 75 patients with diminished ovarian reserve (OR), group 2 included 70 patients with normal OR. Diminished OR was defined as serum Anti-Müllerian hormone (AMH) level <1.1 ng/mL. Pelvic ultrasound (US) was performed in the mid-secretory phase before and 6–12 months after surgery. We measured endometrial thickness, endometrial pattern, visualization of basal and spiral arteries by 2D ultrasound, volume and volumetric blood flow in the endometrial and subendometrial regions by 3D ultrasound. Results. The analysis revealed endometrial dysfunction in patients with diminished OR before and after surgery, however there was a trend towards improvement in all the examined parameters after 12 months. In patients with normal OR before surgery, endometrial parameters did not differ from the population, but more persistent abnormalities were noted in the postoperative period. Conclusion. The 3D ultrasound technique provides an objective assessment of morphological and functional features of the endometrium and allows to identify markers of endometrial dysfunction. Key words: benign ovarian tumors, volumetric blood flow, ovarian reserve, 3D ultrasound, endometrium For citation: Solomatina A.A., Mikhaleva L.M., Tyumentseva M.Yu., Bratchikova O.V., Khamzin I.Z., Tumasyan E.A., Gashimova A.I., Ismayilova P.D. Morphological and functional features of the endometrium in patients before and after ovary-sparing surgery for benign ovarian tumors. Vopr. ginekol. akus. perinatol. (Gynecology, Obstetrics and Perinatology). 2022; 21(3): 45–52. (In Russian). DOI: 10.20953/1726-1678-2022-3-45-52

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