Reply: The heterogeneity of endometriotic lesions could be explained by their progesterone resistance
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Abstract
Sir, We thank Professor Donnez for his interest and considered response in regard to our article (Colgrave et al., 2020). In current practice, a pathologist will diagnose endometriosis using sections from biopsies stained with haematoxylin and eosin. The primary aim of Colgrave et al. (2020) was to determine whether menstrual cycle-related and other clinically useful histological lesion features could be identified using these routine pathology processes without introducing additional immunohistochemical protocols. For this reason, we did not include immunohistochemical studies in this project. However, we agree with Professor Donnez that ongoing research examining lesion characteristics including steroid receptors and specific immune cell makers using samples available to us from our extensive and well-annotated tissue bank would be invaluable and is planned. Also, progesterone resistance may well contribute to the heterogeneity we observed, and it will be fascinating to determine whether steroid receptor expression relates to glandular (as...
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Cites (4)
- Immunohistochemical analysis of proliferative activity and steroid receptor expression in peritoneal and ovarian endometriosis 1997
- Ultrastructural changes in endometriotic implants during the menstrual cycle. 1981
- Superficial peritoneal endometriotic lesions are histologically diverse and rarely demonstrate menstrual cycle synchronicity with matched eutopic endometrium 2020
- Correlação dos aspectos laparoscópicos com as alterações histológicas glandulares das lesões endometrióticas peritoneais 2004
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References (6)
- Correlação dos aspectos laparoscópicos com as alterações histológicas glandulares das lesões endometrióticas peritoneais via openalex
- Immunohistochemical analysis of proliferative activity and steroid receptor expression in peritoneal and ovarian endometriosis via openalex
- Superficial peritoneal endometriotic lesions are histologically diverse and rarely demonstrate menstrual cycle synchronicity with matched eutopic endometrium via openalex
- Ultrastructural changes in endometriotic implants during the menstrual cycle. via openalex
- W2210940027 via openalex
- W6716512485 via openalex
Cited by (1)
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- europepmc
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- openalex
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- pubmed
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