Polymorphisms of the GSTT1 and GSTM1 genes in women of central Serbia: Absence of association with uterine myoma

Slobodan Arsenijević, Biljana Ljujić, Ivana Stošić, Darko Grujičić, Darko Marinković, Olivera Milošević-Djordjević
In: Archives of Biological Sciences · 2013 · vol. 65(2) , pp. 415–420 · doi:10.2298/abs1302415a · W2122929765
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This study investigated GSTT1 and GSTM1 null genotypes in Serbian women and found no association with uterine myoma risk in patients compared to controls.

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This study examined whether GSTT1 and GSTM1 null genotypes, which code for glutathione S-transferase enzymes involved in cellular protection, were associated with uterine myoma risk in women from central Serbia. It included 34 clinically diagnosed myoma patients and 35 healthy controls, with genotypes determined using multiplex PCR, and compared null genotype frequencies and combinations. The authors found no significant differences in GSTT1 or GSTM1 null genotypes between patients and controls and no statistically significant risk associated with the GSTT1 null/GSTM1 null combination relative to GSTT1 positive/GSTM1 positive. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Since glutathione S-transferase (GST) enzymes are involved in cellular protection, we aimed to determine the distribution of GSTT1 and GSTM1 null genotypes in women in central Serbia in order to assess the risk of development of uterine myoma. The study consisted of 34 clinically diagnosed uterine myoma patients and 35 healthy control women. Analyses of GST polymorphism were carried out by multiplex PCR. Our results showed no significant differences in the GSTT1 and GSTM1 null genotypes between the patients and controls. Using the GSTT1 positive/GSTM1 positive combination as reference, there was no statistically significant risk of uterine myoma with the combination of GSTT1 null and GSTM1 null genotypes. We conclude that polymorphism of both GSTT1 and GSTM1 genes, alone or in combination, did not present the main risk for uterine myoma in women from central Serbia.
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Archives of Biological Sciences 2013 Volume 65, Issue 2, Pages: 415-420 Polymorphisms of the GSTT1 and GSTM1 genes in women of central Serbia: Absence of association with uterine myoma Arsenijević S. (Faculty of Medicine, Kragujevac) Since glutathione S-transferase (GST) enzymes are involved in cellular protection, we aimed to determine the distribution of GSTT1 and GSTM1 null genotypes in women in central Serbia in order to assess the risk of development of uterine myoma. The study consisted of 34 clinically diagnosed uterine myoma patients and 35 healthy control women. Analyses of GST polymorphism were carried out by multiplex PCR. Our results showed no significant differences in the GSTT1 and GSTM1 null genotypes between the patients and controls. Using the GSTT1 positive/GSTM1 positive combination as reference, there was no statistically significant risk of uterine myoma with the combination of GSTT1 null and GSTM1 null genotypes. We conclude that polymorphism of both GSTT1 and GSTM1 genes, alone or in combination, did not present the main risk for uterine myoma in women from central Serbia. Keywords: Uterine myoma, GSTT1, GSTM1, polymorphism, central Serbia Projekat Ministarstva nauke Republike Srbije, br. III41010 i br. ON 175103 https://doi.org/10.2298/ABS1302415A Full text ( 702 KB) Cited by Ljujić Biljana (Faculty of Medicine, Center for Molecular Medicine and Stem Cell Research, Kragujevac) Stošić Ivana (Faculty of Science, Kragujevac) Grujičić D. (Faculty of Science, Kragujevac) Marinković D. (Serbian Academy of Sciences and Arts, Belgrade) Milošević-Đorđević Olivera (Faculty of Medicine, Kragujevac + Faculty of Science, Kragujevac)

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