Tumor-like intravascular proliferations of the stroma in adenomyosis

Sieiński W, W Sieiński
Patologia polska · 1993 · vol. 44(1) , pp. 1–4 · PMID:8488076 · W110178614
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This study investigated adenomyosis cases and identified tumor-like intravascular proliferations of the stroma, originating from perivascular stromal proliferation in deep adenomyosis, occurring most frequently in younger patients and hyperplastic adenomyosis.

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Abstract

Two hundred cases of adenomyosis have been studied in order to clarify the origin and significance of intravascular endometrial tissue in adenomyosis. A tumor-like intravascular proliferation of the adenomyotic stroma (IVSP) has been found in 17.5% of the cases. An endolymphatic proliferation (35 cases) was occasionally accompanied by an intravenous proliferation (3 cases). IVSP originated from a perivascular stromal proliferation (PVSP) and occurred only in deep adenomyosis. IVSP was focal and showed no atypia. It was significantly most frequent in patients 50-53 years of age and more frequent in patients up to 53 years than in those over 53. The frequency of occurrence of PVSP and IVSP was related to the histologic features of adenomyosis and the endometrium and was highest in hyperplastic adenomyosis and in adenomyosis accompanied by hyperplasia of the endometrium. The study suggests that PVSP and IVSP develop in the areas of adenomyotic stroma stimulated by estrogen and nonresponsive to progesterone. The differential diagnosis of tumor-like and sarcomatous IVSP, and histogenesis of adenomyosis are discussed.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometriosis Uterine Neoplasms Adult Adult Aged Aged Aged, 80 and over Aged, 80 and over Endometriosis Endometriosis Female Female Humans Humans Middle Aged Middle Aged Myometrium Myometrium Myometrium Stromal Cells

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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SciLite annotations

chemicals 2
estrogen progesterone

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