Influence of ozone therapy on emotional and pain stress in women with adenomyosis

Relevance. Adenomyosis (or endometriosis) is a common and intractable disease, which, according to various studies, affects up to 45 % of women of reproductive age worldwide and is often aggravated by the presence of chronic pelvic pain leading to the development of psycho-emotional disorders. Objective: To study the effect of complex treatment, including ozone therapy, on emotional and pain stress in women with diffuse adenomyosis stage II. Subject and methods. An open randomized controlled study was conducted in 40 women with stage II diffuse adenomyosis aged 32.5 ± 9.4 years, who were divided into two groups. Group 1 (control, n = 10) received standard drug therapy; group 2 (main group, n = 30) received additional ozone therapy. The effectiveness of the treatment was assessed using the VAS scale and the MH component of the SF-36 questionnaire, as well as statistical analysis before treatment, after treatment, and after 1, 3 and 6 months of follow-up. Results and discussion. Before the start of treatment, the patients in both groups showed significant differences in the VAS scale and the MH component compared to the norm, which confirmed a significant deterioration in their socio-psychological status, as well as the presence of severe pain. After the course of treatment and up to 6 months in the 2nd (main) group, the VAS score and MH components tended to their physiological norm. At the same time, in the patients in the 2nd (main) group, a statistically significant strong inverse correlation between VAS scores and the MH component was revealed. In the patients in the 1st (control) group, the studied parameters changed little during treatment, which was evidence of the insufficient analgesic effect of drug therapy and a high level of neuropsychic distress and emotional instability in these patients. Conclusion. The inclusion of ozone therapy in complex treatment for the patients in the 2nd (main) group contributed to a decrease in the severity of pain and symptoms of mental trauma. In addition, the trend line of the VAS indicator and the MN component tended to its normal values, which indicated a positive forecast for two more future periods. In the patients in the 1st (control) group who received only drug therapy, no significant improvement was observed.