Influence of ozone therapy on emotional and pain stress in women with adenomyosis

Ya. I. Uraeva, И. И. Иванова, Н. Н. Лазаренко
In: Fizioterapevt (Physiotherapist) · 2023 · pp. 33–40 · doi:10.33920/med-14-2305-04 · W4387909741
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⚙ AI-generated summary by claude@2026-06, 2026-06-11 ⓘ

This study found that adding ozone therapy to standard treatment for adenomyosis reduced pain and improved emotional well-being more effectively than standard treatment alone.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-15 · read from full text ⓘ

The paper aims to evaluate how комплексное лечение, включающее озонотерапию, affects emotional-and-pain stress in women with diffuse adenomyosis stage II, focusing on the context that chronic pelvic pain from adenomyosis can be associated with emotional and functional disruptions. It describes an included population of reproductive-age women with clinically and lab-confirmed diffuse adenomyosis stage II, chronic pelvic pain syndrome, and informed consent, while excluding women under 20 or over 45, those with relevant medication allergies or intolerance, and those with acute disease stages. The provided excerpt does not report results or specific quantitative findings, and explicitly frames the study as an investigation of influence without detailing a limitation beyond the stated inclusion/exclusion criteria. Relevance to endometriosis: adenomyosis is discussed alongside endometriosis early in the introduction as a related, hard-to-cure condition, though the paper’s main focus is adenomyosis (diffuse stage II) and the emotional-pain stress impact of ozone therapy.

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Abstract

Relevance. Adenomyosis (or endometriosis) is a common and intractable disease, which, according to various studies, affects up to 45 % of women of reproductive age worldwide and is often aggravated by the presence of chronic pelvic pain leading to the development of psycho-emotional disorders. Objective: To study the effect of complex treatment, including ozone therapy, on emotional and pain stress in women with diffuse adenomyosis stage II. Subject and methods. An open randomized controlled study was conducted in 40 women with stage II diffuse adenomyosis aged 32.5 ± 9.4 years, who were divided into two groups. Group 1 (control, n = 10) received standard drug therapy; group 2 (main group, n = 30) received additional ozone therapy. The effectiveness of the treatment was assessed using the VAS scale and the MH component of the SF-36 questionnaire, as well as statistical analysis before treatment, after treatment, and after 1, 3 and 6 months of follow-up. Results and discussion. Before the start of treatment, the patients in both groups showed significant differences in the VAS scale and the MH component compared to the norm, which confirmed a significant deterioration in their socio-psychological status, as well as the presence of severe pain. After the course of treatment and up to 6 months in the 2nd (main) group, the VAS score and MH components tended to their physiological norm. At the same time, in the patients in the 2nd (main) group, a statistically significant strong inverse correlation between VAS scores and the MH component was revealed. In the patients in the 1st (control) group, the studied parameters changed little during treatment, which was evidence of the insufficient analgesic effect of drug therapy and a high level of neuropsychic distress and emotional instability in these patients. Conclusion. The inclusion of ozone therapy in complex treatment for the patients in the 2nd (main) group contributed to a decrease in the severity of pain and symptoms of mental trauma. In addition, the trend line of the VAS indicator and the MN component tended to its normal values, which indicated a positive forecast for two more future periods. In the patients in the 1st (control) group who received only drug therapy, no significant improvement was observed.
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Аденомиоз (или эндометриоз) является распространенным и трудноизлечимым заболеванием, поражающим, по данным различных исследований, до 45 % женщин репродуктивного возраста во всем мире [1, 2]. Однако, несмотря на его распространенность, на сегодняшний день ученые не оставляют попыток найти характерные симптомы для своевременной постановки его диагноза и эффективные способы лечения данной патологии [3]. При этом эндометриоз влияет на психологическое, физическое состояние женщин, ограничивает их социальную активность, а также негативно влияет на фактор рождаемости [4]. В настоящее время социальная ценность человека приобретает особую актуальность и становится центральной в современной экономической и политической психологии [5]. Жизнедеятельность человека обеспечивается его здоровьем [6]. С этой точки зрения аденомиоз как причина нарушения нормального функционирования органов и систем может привести к отклонению на эмоционально-психическом уровне, особенно если он протекает на фоне гормональной перестройки, которая отягощается наличием хронических тазовых болей, а также половой дисфункцией [7]. При этом аденомиоз встречается у социально активных женщин репродуктивного возраста. Он вызывает тяжелую социальную дезадаптацию и значительно ухудшает качество жизни женщин [8]. Актуальность: изучить влияние комплексного лечения, включающего озонотерапию, на эмоционально-болевой стресс у женщин с диффузным аденомиозом II стадии. Критерии включения в исследование: • установленный диагноз диффузного аденомиоза II стадии, подтвержденный клинико-лабораторными и функциональными методами; • наличие хронического тазового болевого синдрома; • репродуктивный возраст; • подписание информированного согласия пациенткой. Критерии невключения в исследование: • возраст женщины моложе 20 лет и старше 45 лет; • аллергические реакции в анамнезе или индивидуальная непереносимость используемых лекарственных средств; • острая стадия любого заболевания;

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Outcome instruments

VAS-pain

Condition tags

endometriosisadenomyosischronic_pelvic_pain

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