[Results of IVF in women with endometriosis]
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This study investigated IVF outcomes in women with endometriosis, finding that severe disease negatively impacts ovarian reserve and pregnancy rates, while surgical treatment may improve results, particularly for younger women.
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Abstract
When associated with infertility, endometriosis often requires in vitro fertilization (IVF). The need of IVF instead of other Assisted Reproductive Technologies is correlated with the severity of the lesions and associated tubal pathology. Results of IVF (in terms of pregnancy rates), are influenced by the existence of endometriosis, but this influence remains controversial, and focused on three possible points: poor ovarian reserve (and ovarian response), poor quality of oocytes and embryos, poor implantation. It seems that mild and moderate endometriosis (I-II American Fertility Society score) has few deleterious effect on ovarian reserve, ovarian response, and pregnancy rates. All these parameters are decreased by the existence of severe endometriosis (III-IV AFS). Its surgical treatment appears to improve the results of IVF, notably in women under 35. But iterative surgery of endometriomas might be deleterious for ovarian function. Previous treatment by Gn-RH agonists also improves the outcome of IVF, whereas ICSI does not modify either the biological parameters, nor the pregnancy rates. Ovarian hyperstimulation in women with endometriosis might increase the severity of the lesions and the risk of complications: the use of unstimulated cycle (n-IVF) in young patients with normal ovarian reserve might be interesting.
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Cited by (15)
- A large-scale causal analysis of gut microbiota and endometriosis associated infertility: A Mendelian randomization study 2024
- Morphokinetic analysis of early human embryonic development and its relationship to endometriosis resection: a retrospective time-lapse study using the KIDScore™ D3 and D5 implantation data algorithm 2023
- Endometrial receptivity in women with endometriosis 2023
- Pre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial 2022
- Factors affecting clinical outcomes after IVF-ET for infertile young patients with ovarian endometrioma: A 5-year retrospective cohort study 2022
- Fertility Outcomes After Laparoscopic Cystectomy in Infertile Patients with Stage III-IV Endometriosis: a Cohort with 6-10 years of Follow-up 2020
- Fertility-related considerations in endometriosis 2019
- Long-term GnRH agonist therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with endometriosis 2019
- The effect of surgical management of endometrioma on the IVF/ICSI outcomes when compared with no treatment? A systematic review and meta-analysis 2018
- Morphological and immunohistochemical characterization of spontaneous endometriosis in rhesus macaques (Macaca mulatta) 2017
- A low-testosterone state associated with endometrioma leads to the apoptosis of granulosa cells 2014
- The effect of endometriosis on in vitro fertilisation outcome: a systematic review and meta-analysis 2013
- Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility 2012
- <i>In vitro</i>fertilization outcomes in patients with advanced endometriosis after surgical treatment 2011
- Outcome of the IVF for the Patients with Endometrioma Associated Infertility 2009
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- europepmc
- last seen: 2026-10-15T06:08:49.021275+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:02:24.140261+00:00
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