Multiple Mechanisms Controlling Uterine Function: Editorial to Special Issue "Molecular Mechanisms of Uterine Receptivity for Embryo Implantation".

Jan Tesařík

doi:10.3390/ijms242417629

Multiple Mechanisms Controlling Uterine Function: Editorial to Special Issue "Molecular Mechanisms of Uterine Receptivity for Embryo Implantation".

Jan Tesařík

International journal of molecular sciences · 2023 · doi:10.3390/ijms242417629 · PMID:38139454 · PMC10744035

OA: gold CC-BY-4.0

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This paper discusses the multiple molecular mechanisms that control uterine receptivity, which is essential for embryo implantation, nourishment, and survival.

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This editorial introduces a special issue focused on the molecular mechanisms governing uterine receptivity and embryo implantation. It highlights several included studies, such as one examining HOXA10 gene expression in women with endometriosis and others investigating endometrial microbiota, proteome changes from scratching, and non-coding RNA biomarkers for pregnancy outcomes. The text serves as an overview of diverse biological pathways influencing reproductive health rather than presenting new primary data. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

Uterine (endometrial) receptivity is the ability of the endometrium to successfully attach to the embryo, to promote its implantation, to nourish it and keep it alive [...].

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List

Wu, H.-M.; Chen, L.-H.; Huang, H.-Y.; Wang, H.-S.; Tsai, C.-L. EGF-enhanced GnRH-II regulation in decidual stromal cell motility through Twist and N-cadherin signaling. Int. J. Mol. Sci . 2023 , 24 , 15271. https://doi.org/10.3390/ijms242015271 . Yu, S.-L.; Jeong, D.-U.; Noh, E.-J.; Jeon, H.J.; Lee, D.C.; Kang, M.; Kim, T.-H.; Lee, S.K.; Han, A.R.; Kang, J.; et al. Exosomal miR-205-5p improves endometrial receptivity by upregulating E-cadherin expression through ZEB1 inhibition. Int. J. Mol. Sci . 2023 , 24 , 15149. https://doi.org/10.3390/ijms242015149 . Scheliga, I.; Baston-Buest, D.M.; Poschmann, G.; Stuehler, K.; Kruessel, J.-S.; Bielfeld, A.P. Closer to the reality—Proteome changes evoked by endometrial scratching in fertile Vanstokstraeten, R.; Callewaert, E.; Blotwijk, S.; Rombauts, E.; Crombé, F.; Emmerechts, K.; Soetens, O.; Vandoorslaer, K.; De Geyter, D.; Allonsius, C.; et al. Comparing vaginal and endometrial microbiota using culturomics: Proof of concept. Int. J. Mol. Sci . 2023 , 24 , 5947. https://doi.org/10.3390/ijms24065947 . Lazim, N.; Elias, M.H.; Sutaji, Z.; Abdul Karim, A.K.; Abu, M.A.; Ugusman, A.; Syafruddin, S.E.; Mokhtar, M.H.; Ahmad, M.F. Expression of HOXA10 gene in women with endometriosis: A systematic review. Int. J. Mol. Sci . 2023 , 24 , 12869. https://doi.org/10.3390/ijms241612869 . females. Int. J. Mol. Sci . 2023 , 24 , 13577. https://doi.org/10.3390/ijms241713577 . Huang, W.; Chen, A.C.H.; Ng, E.H.Y.; Yeung, W.S.B.; Lee, Y.L. Non-coding RNAs as biomarkers for embryo quality and pregnancy outcomes: A systematic review and meta-analysis. Int. J. Mol. Sci . 2023 , 24 , 5751. https://doi.org/10.3390/ijms24065751 .

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Conflicts

The author declares no conflict of interest.

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