Medical Therapy of Endometriosis

Ae-Ra Kang, Jun Young Hur
In: Journal of the Korean Medical Association · 2010 · vol. 53(5) , pp. 424 · doi:10.5124/jkma.2010.53.5.424 · W1966992126
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review discusses conventional medical therapies for endometriosis, including GnRH agonists, Danazol, progestogens, and oral contraceptives, and introduces newer targeted agents while noting the need for further evaluation.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-12 · read from full text ⓘ

This paper is a narrative review on medical therapy for endometriosis, describing major estrogen-dependent disease features and summarizing conventional and newer pharmacologic options used in clinical practice. It covers established agents such as GnRH agonists, danazol, progestogens, and oral contraceptives, and discusses additional targeted agents that have emerged alongside increased knowledge of endometriosis, including considerations related to hormonal regulation and side effects in cited studies (e.g., bone density and recurrence outcomes). A stated limitation is that effectiveness and safety of newer agents require further study. This paper is centrally about endometriosis — it specifically reviews and summarizes medical (pharmacologic) treatments for endometriosis and their evidence base.

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Abstract

Endometriosis is a common, benign, and chronic gynecologic disorder. It is an Estrogen dependent disease that can cause pelvic pain, dysmenorrhea, and infertility. GnRH agonists, Danazol, progestogens, and oral contraceptives have been conventionally used for the medical treatment of endometriosis. Increasing knowledge about endometriosis has introduced more new targeted agents for endometriosis. Further study might be required to evaluate effectiveness and safety of new agents.
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424ߨ Pharmacotherapeutics ੗ ࢿ ࠁ ੌ ૐ਷ ਘ҃ ੸ੋ ஖ য ੄ ਗ஗੉ ৉ ֙ ాૐઑ ח۽ٜ ׮ ॳ੉Ҋ ੓ਵ ਑ ੘ਊਸ ઴ ੗Ҿ ఖ੸ ਊ୓ ઑ੺ઁ 413. $09 রઁઁ ആҙ ׮ ૐ੄ बೠ ח׮ ജ੗੄ ੸ ੽Ӕ੉ ׮ػ ߨ Medical Therapy of Endometriosis ੋҗ೟Үप ]Ae-Ra Kang, MD hJun Young Hur, MD Department of Obstetrics and Gynecology, Korea University College of Medicine * Corresponding author : Jun Young Hur E - mail : [email protected] J Korean Med Assoc 2010; 53(5): 424 - 429 E ndometriosis is a common, benign, and chronic gynecologic disorder. It is an Estrogen dependent disease that can cause pelvic pain, dysmenorrhea, and infertility. GnRH agonists, Danazol, progestogens, and oral contraceptives have been conventionally used for the medical treatment of endometriosis. Increasing knowledge about endometriosis has introduced more new targeted agents for endometriosis. Further study might be required to evaluate effecti- veness and safety of new agents. Keywords:Endometriosis; Medical treatment ೨बਊয  ߨ Abstract ഈഥ૑ 425 ߨMedical Therapy of Endometriosis ٜ ҃ҳೖ੐ড ݄ ੄ ನ ࣘ OPS ਸ ೣਬೠ ҃ҳೖ ۽ ਍EFTPHFTUSFMೣਬઁઁ ৉द ബҗ੸ ࢎ ׮ بߣ ҃ҳೖ੐ ܳب بۄ ૑ ঋ਷ ҵ ҃ҳೖ੐ ੄ х ҃ҳೖ੐ઁ ੄ ࣻ ੸ ҃ҳೖ੐ ࠺ ࢲ ߨ ׮ ҵҗ ઱ӝ੸ ҃ҳ ܳ ਃ ੉ ਬ੄ ੸ ҃ҳೖ੐ ו   ׮ ী ബҗ Ѫ੉ р ੿ חࠁ ח Ү੸ ਊ੉ೞҊ ࢶ ׮ػ ѱझషѲ 1SPHFTUPHFO ѱझషѲ਷.1" NFESPYZQSPHFTUFSPOF BDF ݄ ബ ਤ୷ 1 NBUSJYNFUBMMP FDUPQJD &OEP ׮ PSUFTUP ۽ ୭ ъ҃ਵ ܳ ೧ ࢲ ׮ ੿ ী ӛ੿੸ੋ ী ੢੼੉ ੓ ੄ ח ػ ੉ ׮ ࢶ HPOBEPUSPQIJO ੄ IZESPYZQSPHFTUFSPOF ҃ҳೖ੐ড EFTPHFTUSFM 426ߨ Kang ARhHur JY Үೠ োҳী ח ജ੗о ҃ ೖ೧ ਄ ׮ ੄ উ о੢ ܖ 1" %FQPUGPSNVMBUJPOPG.F ా  NHਸ ѐਘী ࠼ ب࠼ ۽ ࠗ ѐ ড ࣻ   ׮ ੑറ ੗Ҿղ੢ Ѳ ର੸ੋ ബҗо ֙ ୹ೞৈ ী ా ա അ੤ ׮ য় ੓ਵ ా੉ա х৏੄ ਤ೷੉ ઺ ੗Ҿ Ү ੉  ী ׮ ੘ਊઁ (O3)"HPOJTU ࣻ ػ хӝо ӡয ୷ਸ ೞೱઑ੺ EPXO SFHVMBUJPO ೞҊ ੷ ೞৈ ੼૓੸ਵ ೠ ੗ ૓1MBTNJOPHFOBDUJ ࠁܳ റ ਊ ܫߊ ࢎ ࢲ ࢠ ਊೞ૑ ঋ ੘ਊઁ ׮ ഘ ੘ਊ੉ ੓ਵ Ҋ ਷ ઺ ܰ ؘח ࠙ހܰ ੗ ੄ ੤ ހܰ ࢠ ੉ ੗ӓഐ ׮ࠁ ৓ ഈഥ૑ 427 ߨMedical Therapy of Endometriosis ߊ ѐ ੗ӓഐ ࣗ ৮ೞӝ ਤ೧ ੉ ਷ ઴ TUSPHFO ׮݃ ড  _QHNM੄ ীझ౟ ծ ੉ ੘ਊ੉ ੓ਵա  ড  _QHNM੄ ੗ӓೞ૑ ঋਵ दெ ݶ ח ߽ۿ ৮ োҳী ׮ աઔ %BOB[PM ട୓ഋ ਸ রઁ ׮ ੌ ҙ଴ ా੉ ѐਘ উী അ੷൤ х غࣘ ঻Ҋ ׮ ۽ ࣗݾ ૕৏ ١ ۽ աઔ ೣਬ Ҋ ੓ਵա ׮ FTUSJOPOF ࢲ ૑ ঋਵ ѱझ ܰ ੄MZTPTPNBM ѱझషѲਸ রઁ ח ࢎ ٘ ੘ਊ੉ ੓Ҋ)%- DIPMFTUFSPM ࠗ؀׮ ਫ਼੤੸ ׮ ٜب রઁઁ "SPNBUBTF*OIJCJUPST ನ HSBOV झ 4U"3 ਸ DZUP оBOESPTUFOFEJPO ݄݀ ನ TZODJUJPUSPQIPCMBTU  Ҋജ੄ ನ GJCSP ੸ ח Ѫਵ ח חࢲ ׮ ࢲ झ ࣗ ನ য ਽੉ ী ઺ਃೠ ীझ౟ ਵ ড ܐ ׮ ҃ ઁഋ਷ OBTUSB[PMF "SJNJEFY ৬ -FUSP[PMF ঻ রઁઁੋBOBTUSP[PMF  MFUSP ਋ਘೠ ׮ ਷ MFUSP[PMF  NHਸ /PSFUIJO ъ҃ೞ Ҋ ೮ ਷ BOBTUSP[PMF  NHҗ HPTFSFMJOF ࢚ ө૑੄ ബҗ੄ ӝ ਸরઁೞҊ ೠ ੉ Ѳ ೤ ݡغࢿ غ ݄ ۾ب ਸ ਊೡ ب޻ ੗ӓ ୡӝ ҃ҳೖ੐ઁ৬ э ׮ػ ਊ୓ ઑ੺ઁ413. 4FMFDUJWF 1SPHFTUFSPOF3FDFQUPS.PEVMBUPS ࣻۿ ӡ೦ઁ ഑਷ ੘ਊ ࣻۿ ѱझప USBOTDSJQUJPO  ઑ੺਷ DPSFHVMBUPS ؘח ۿ ೞ ਊ୓ী ۿ DP ૕ BOUB DP ૑Ҋ ੓ਵ ఖ੸ ೐ ۿ ݓزࢶ ୷ਸ ૐо ੘ ਘ दః૑ ঋਵ ৬ ׮ TPQSJTOJM  ݽࢲ ֙ݴ ࠁ 428ߨ Kang ARhHur JY ഈഥ૑ 429 ׮ ࢚ ଵ ٜ غ ୶о੸ੋ োҳо ೙ ׮ػ ٜب রઁઁ 5VNPS /FDSPTJT 'BDUPS 5/' JOIJCJUPS  ..1 NBUSJY ѱ ׮ ਷ ҙब੉ 5*.1   5JTTVF*OIJCJUPSTPGNBUSJY ੄FOEPQFQ UJEBTFੋ ..1 NBUSJY NFUBMMPQSPUFJOBTF ੄ ੘ਊਸ র ъ ղ ੗Ҿ৻ ੗ ࠙۠ ۽ ׮ ࠁ۽ ޷ח ׮ Ӓ ਊী ૐ੄ ੤ ੗ ߊ ܖ ׮ػ ೴ 11. Seracchioli R, Mabrouk M, Frasca C, Manuzzi L, Savelli L, Venturoli S. Long-term oral contraceptive pills and postopera- tive pain management after laparoscopic excision of ovarian endometrioma: a randomized controlled trial. Fertil Steril 2009. 12. Chu MC, Zhang X, Gentzschein E, Stanczyk FZ, Lobo RA. For- mation of ethinyl estradiol in women during treatment with norethindrone acetate. J Clin Endocrinol Metab 2007; 92: 2205-2207. 13. Cundy T, Evans M, Roberts H, Wattie D, Ames R, Reid IR. Bone density in women receiving depot medroxyprogesterone acetate for contraception. BMJ 1991; 303: 13-16. 14. Jee BC, Lee JY, Suh CS, Kim SH, Choi YM, Moon SY. Impact of GnRH agonist treatment on recurrence of ovarian endome- triomas after conservative laparoscopic surgery. Fertil Steril 2009; 91: 40-45. 15. Soysal S, Soysal ME, Ozer S, Gul N, Gezgin T. The effects of post-surgical administration of goserelin plus anastrozole compared to goserelin alone in patients with severe endome- triosis: a prospective randomized trial. Hum Reprod 2004; 19: 160-167. ߨMedical Therapy of Endometriosis Peer Reviewers’ Commentary ਍ ড ী ੄ ݺ ۽ ࢲ ׮ػ ಞ૘ਤਗഥ>

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endometriosisdysmenorrheainfertility

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