Evidence of interplay between plasma endothelin-1 and 17β-estradiol in regulation of uterine blood flow and endometrial growth in infertile women

Bruno Cacciatore, Niklas Simberg, Aila Tiitinen, Olavi Ylikorkala
In: Fertility and Sterility · 1997 · vol. 67(5) , pp. 883–888 · doi:10.1016/s0015-0282(97)81401-x · PMID:9130894 · W2108050793
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This study investigated the interaction of plasma endothelin-1 and 17β-estradiol in regulating uterine blood flow and endometrial growth among infertile women.

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Abstract

ObjectiveTo determine the effects of gonadotropin-induced ovarian stimulation on the plasma levels of endothelin-1 as well as on uterine blood flow and endometrial thickness.DesignControlled cross-over clinical study.SettingAcademic research environment.Patient(s)Eighteen volunteer infertile women (31.4 +/- 2.5 years, mean +/- SE) participating in an IVF-ET program.Intervention(s)Transvaginal Doppler ultrasound was performed and blood samples were collected 4 days after the LH surge in a spontaneous cycle and 4 days after hCG administration in a subsequent gonadotropin-stimulated cycle.Main outcome measure(s)Plasma levels of E2, P, and endothelin-1; uterine artery pulsatility index; and endometrial thickness.Result(s)Stimulated cycles were associated with significantly higher E2 levels (101.0 +/- 10.2 versus 723.5 +/- 57.3 pg/mL [conversion Factor to SI unit, 3.671]; spontaneous versus stimulated), thicker endometrium (9.2 +/- 2.5 versus 11.4 +/- 2.9 mm), and lower endothelin-1 levels (2.5 +/- 0.1 versus 2.1 +/- 0.1 pg/mL [conversion factor to SI unit, 0.4]) and pulsatility index (3.22 +/- 0.12 versus 2.63 +/- 0.08) than spontaneous cycles. Endothelin-1 correlated negatively with E2 (r = -0.38), but not with P or pulsatility index. Differences in endothelin-1 and endometrial thickness between spontaneous and stimulated cycles correlated negatively (r = -0.56) with each other.ConclusionOur results suggest an inhibitory role for E2 in the release of endothelin-1, which could be a factor in the regulation of uterine and endometrial blood flow.

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estradiol
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noordeloos 2009062

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