Possible roles of HLA-G regulating immune cells in pregnancy and endometrial diseases via KIR2DL4

Bai Y, Yixuan Bai, Junhui Liang, Liang J, Liu W, Wei Liu, Fei Wang, Wang F, Li C, Changzhong Li
Journal of Reproductive Immunology · 2020 · vol. 142 , pp. 103176 · doi:10.1016/j.jri.2020.103176 · PMID:32711226 · W3041853378
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This paper explores the potential regulatory functions of HLA-G in immune cells during pregnancy and endometrial diseases by interacting with the KIR2DL4 receptor.

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Abstract

Major histocompatibility complex (MHC) molecules bind peptides originated from cellular synthesis and present them at the cell surface for recognition by receptors on immune cells like T lymphocytes, natural killer (NK) cells or mast cells. Such recognition plays a crucial part in autoimmunity, anti-bacterial, anti-viral and anti-tumor responses. Human leukocyte antigen G (HLA-G) is a member of non-classical HLA class I molecules which has been studied deeply in recent years into its role in pregnancy and endometrial diseases, including endometrial tumor, endometriosis and adenomyosis, etc. Understanding the mechanism of the maintenance of pregnancy and immune escape of endometrial diseases in a HLA-G dependent way is of current interest. Perception from studies in the expression of HLA-G and possible pathways is a vital part of understanding mechanisms related to immune escape.

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Condition tags

endometriosis

MeSH descriptors

Adenomyosis Embryo Implantation Endometrial Neoplasms Endometriosis HLA-G Antigens Receptors, KIR2DL4 Adenomyosis Adenomyosis Cell Communication Cell Communication Embryo Implantation Endometrial Neoplasms Endometrial Neoplasms Endometriosis Endometriosis Endometrium Endometrium Endometrium Female HLA-G Antigens

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europepmc
last seen: 2026-08-01T06:07:04.264727+00:00
openalex
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License: CC0 · commercial use OK