Dr. Tian Xu. Interviewed by Thomas Ni and Rachel Rosenstein

Lab / animal OA: gold
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This interview with Dr. Tian Xu discusses his lab’s use of Drosophila and mouse models to investigate tumorigenesis mechanisms and the development of the piggyBac transposon system for identifying genes in human diseases.

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Abstract

Tian Xu is professor and vice chairman of Genetics at Yale University and a Howard Hughes Medical Institute investigator. His lab is working to understand the mechanisms of tumorigenesis and metastasis using Drosophila and mouse models. Notably, Dr. Xu has developed the powerful piggyBac transposon mutagenesis system, which has allowed investigators to perform forward genetics in mammalian models. This approach should prove instrumental in the identification of important genes involved in human diseases.

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MeSH descriptors

Neoplasms Neoplasms Research Animals Cell Transformation, Neoplastic Connecticut Disease Progression DNA Transposable Elements Drosophila History, 20th Century History, 21st Century Humans Medical Oncology Medical Oncology Mice Neoplasm Metastasis Neoplasms Research Research

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