Endometrial prostaglandins and menorrhagia: influence of a prostaglandin synthetase inhibitor in vivo
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Menorrhagic subjects displayed elevated endometrial prostaglandin levels, which were reduced by mefenamic acid treatment alongside a decrease in menstrual blood loss.
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Abstract
Prostaglandin levels in the human endometrium were determined on day 2 of the menstrual cycle in eumenorrheic subjects and in patients with menorrhagia, dysmenorrhea, or both. Menorrhagic subjects had significantly higher levels of endometrial prostaglandins of the E and F series when compared with eumenorrheics. Prostaglandin E levels were markedly higher than prostaglandin F. In 10 menorrhagic subjects who completed a double-blind clinical study on the effectiveness of mefenamic acid in lowering menstrual blood loss, 9 exhibited statistically significant reduction in endometrial prostaglandin levels. A decrease in menstrual blood loss was also noted during mefenamic acid treatment in these patients. These findings are consistent with the concept that abnormally high uterine prostaglandin levels may be an important etiologic factor in menorrhagia and support the notion that one of the mechanisms of action of nonsteroidal anti-inflammatory agents in the treatment of this menstrual disorder is inhibition of endometrial prostaglandin production.
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- W1775749144 via openalex
Cited by (7)
- Non-steroidal anti-inflammatory drugs for heavy menstrual bleeding 2019
- Medical Management of Heavy Menstrual Bleeding 2015
- Non-steroidal anti-inflammatory drugs for heavy menstrual bleeding 2013
- Nonsteroidal anti-inflammatory drugs for heavy menstrual bleeding 2007
- Nonsteroidal anti-inflammatory drugs for heavy menstrual bleeding 1998
- Medical management of menorrhagia 1992
- Effects of mefenamic acid on menstrual hemostasis in essential menorrhagia 1992
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