Rapidly Progressive Pulmonary Fibrosis in a Patient Treated with Danazol for Idiopathic Thrombocytopenic Purpura

Smita Pakhalé, Yuri Moltyaner, Dean Chamberlain, Neil M. Lazar
In: Canadian Respiratory Journal · 2004 · vol. 11(1) , pp. 55–57 · doi:10.1155/2004/935458 · W147084468
article OA: gold CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-07, 2026-07-29 ⓘ

This case report describes a patient who developed rapidly progressive pulmonary fibrosis, complicated by pneumothoraxes and pneumomediastinum, two months after starting danazol for idiopathic thrombocytopenic purpura.

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Abstract

The case of a patient that developed pulmonary fibrosis two months after initiation of danazol for treatment of idiopathic thrombocytopenic purpura is described. Bilateral pneumothoraxes and pneumomediastinum complicated the rapidly fatal pulmonary fibrosis. An association between danazol therapy and the development of pulmonary fibrosis is suspected. There is only one other case report with this connection in the literature.

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