Fatal acute pulmonary fibrosis in a patient treated by danazol for thrombocytopenia

has prognostic value in lymphoid malignancies such as multiple myeloma and CLL. High P2m values in CLL have been found to correlate mainly with stage of disease and high lymphocyte count 131. Prolymphocytic leukemia is a disease of activated B lymphocytes more differentiated than B-CLL cells. PLL cells express B cell activation antigens CD25, CD38, CD71, FMC7, PCAl, and RABl 141. We found a significantly higher level of p2m in PLL than in CLL patients. Our results indicate that P2m levels may be an additional marker of B-cell activation to further characterize lymphoid diseases arrested in different stages of maturation.