Prevalence of dysmenorrhea and predictors of its pain intensity among Palestinian female university students.

This was a cross sectional study carried out at An-Najah National University, the largest university in Palestine with more than 10,000 female students distributed across different specialization. This study was carried out during the fall semester of 2016 and included female students from different specialities. The researchers reviewed several articles published among female university students in the Middle East region and developed a questionnaire to be used for the purpose of this survey study. The questions developed in the questionnaire were similar to those found in previously published reports [ 9 , 27 , 28 ]. The language of the questionnaire was Arabic and was written in a very simple straightforward language. A statement regarding the presence of any diagnosed pelvic pathological conditions was stated at the beginning of the questionnaire and students with such pathology were asked not to answer the questionnaire and return it back to the investigators. Therefore, those who filled the questionnaire were students with no pelvic pathological problems and pain due to menstruation is mostly a primary dysmenorrhea. The questionnaire included 30 questions grouped into three sets of questions. The first set of questions were questions pertaining to reproductive health and life such as age at menarche, length of menstruation, regularity of the menstrual cycle, presence of pain and accompanied symptoms, pain management, life style questions including nutritional habits, place of living, degree of stress, physical activity, and questions pertaining to body weight. The second set of questions included a list of symptoms that could be experienced by females with dysmenorrhea and the participants were asked to choose the list of symptoms that they experience. The third set of questions consisted of visual analogue scale for the student to choose a number representing most close painful feeling during dysmenorrhea. No validation of the visual analogue scale was carried out and therefore the pain intensity reported by the participants remained an approximation of reality rather than an accurate measure. This approximation of pain intensity using the visual analogue scale was used to assess dysmenorrhic pain in several published articles [ 29 – 32 ]. The questionnaire took an average of 10 min to answer all the questions and all the questions asked pertained to the last six months. A copy of the questionnaire (Arabic language) is available upon request from the corresponding author. The questionnaires were distributed to female students at the university break time from 12 to 1 pm. The questionnaires were distributed in seven different sites in the university where students from all colleges usually spend their break time. The distribution and collection process were carried out for four consecutive days with 300 questionnaires being distributed daily. The distribution and collection of the questionnaires were carried out by two co-authors (H.H and A.M). The researchers estimated the sample size using Raosoft calculator assuming a response rate of 50% and a confidence level of 95%. The estimated sample size was 380, however, the researchers decided to distribute a minimum of 1200 questionnaire to account for any un-expected scenarios of rejection to participate. The questionnaire included no questions that involve name of the student to ensure confidentiality. Furthermore, an approval was obtained from the institutional review board (IRB) at An-Najah National University was obtained to carry out the study among the female university students. Since no clinical intervention or blood testing was involved in the study, verbal consent, and not a written consent, was obtained from all participants according to IRB regulations. All data collected were entered in the Statistical Package for Social Sciences (SPSS) 20 software after coding all answers. The variables were then categorized to facilitate the analysis. Examples of categorization include age ( 14 years), regular menses (always or “not always”), smoking (yes or no), breakfast (always or sometimes/never), and others as shown in Table  1 in result section. Statistical description for categorical variables include frequency and percentage. For the visual analogue scale, it was scaled from 1 to 10. We considered any score ≤ 4 to be of a mild pain while any score ≥ 5 to be as moderate/sever pain. Univariate analysis for the presence of dysmenorrhea (yes versus no) was carried out with all variables pertaining to demographic, menstrual characteristics, and life style. Univariate analysis was also carried out for dysmenorrhic pain intensity (moderate/severe versus mild). For categorical variables, Chi – square test with a pre-set significance value of ≤0.05 was used to test for significant association with moderate/sever dysmenorrhic pain. The dependent variable was pain severity (mild versus moderate/severe). The independent variables used in the univariate analysis were all categorical variables pertaining to demographics, reproductive health, and life style habits. Multivariate analysis was carried out to find predictors of moderate/severe dysmenorrhic pain. Binary logistic regression was employed using the enter method. The dependent variable was the pain severity (mild versus moderate/severe codes as 0 and 1). The independent variables used in binary logistic regression were all variables with significant p values in univariate analysis. All through the analysis whenever a significance was obtained, the odds ratio (OR) and the 95% confidence interval (CI) of the odds ratio was calculated and presented. Table 1 Univariate analysis for presence of dysmenorrhea among the study participants Variables Total (%) Presence of dysmenorrhea P value YES (%) No (%) College 956 814 (85.1) 142 (14.9) 0.859  Engineering/Science 216 (22.6) 182 (22.4) 34 (23.9)  Humanities and social sciences 592 (61.9) 507 (62.3) 85 (59.9)  M 148 (15.5) 125 (15.4) 23 (16.2) Age (years) 19.73 ± 1.5 0.806    14 301 (31.5) 245 (30.1) 56 (39.4) Regular 0.703  Always 248 (25.9) 213 (26.2) 35 (24.6)  Not always 708 (74.1) 601 (73.8) 107 (75.4) Duration of menses (days) 0.339   ≤ 5 510 (53.3) 429 (52.7) 81 (57)   > 5 446 (46.7) 385 (47.3) 61 (43) Education of the mother 0.464   ≤ High school 625 (65.4) 536 (65.8) 89 (62.7)   ≥ College 331 (34.6) 278 (34.2) 53 (37.3) Education of the father 0.761   ≤ High school 496 (51.9) 424 (52.1) 72 (49.3)   ≥ College 460 (48.1) 390 (47.9) 70 (50.7) Socioeconomic level 0.628   ≤ Average (~  400 USD) 684 (71.5) 580 (71.3) 104 (73.2)   > Average 272 (28.5) 234 (28.7) 38 (26.8) Smoking 0.274  Yes 158 (16.5) 139 (17.1) 19 (13.4)  No 798 (83.5) 675 (82.9) 123 (86.6) BMI 0.099    30 22 (2.4) 18 (2.3) 4 (2.9) Breakfast 0.984  Every day 243 (25.4) 207 (25.4) 36 (25.4)  Sometimes/Never 713 (74.6) 607 (74.6) 106 (74.6) Tea/coffee/Nescafe 0.0748   ≤ 1 cup 312 (32.6) 264 (32.4) 48 (33.8)   ≥ 2 cup 644 (67.4) 550 (67.6) 94 (66.2) Vegetables and fruits 0.804  Never or low 203 (21.3) 172 (21.2) 31 (22)  Moderate 594 (62.3) 506 (62.3) 88 (62.4)  High 119 (12.5) 104 (12.8) 15 (10.6)  Very high 37 (3.9) 30 (3.7) 7 (5) Meat and protein rich diet 0.328  Never or low 227 (23.8) 190 (23.4) 37 (26.2)  Moderate 596 (62.5) 517 (63.6) 79 (56)  High 99 (10.4) 80 (9.8) 19 (13.5)  Very high 32 (3.4) 26 (3.2) 6 (4.3) Sweets and sugary beverages 0.240  Never or low 81 (8.5) 63 (7.7) 18 (12.9)  Moderate 523 (54.9) 452 (55.6) 71 (50.7)  High 290 (30.4) 248 (s) 42 (30)  Very high 59 (6.2) 50 (6.2) 9 (6.4) Salty foods 0.326  Never or low 96 (10.1) 77 (9.5) 19 (13.6)  Moderate 444 (46.6) 387 (47.7) 57 (40.7)  High 319 (33.5) 269 (33.1) 50 (35.7)  Very high 93 (9.8) 79 (9.7) 14 (10) Exercise 0.721  Yes 329 (34.4) 282 (34.6) 47 (33.1)  No 627 (65.6) 532 (65.4) 95 (66.9) Interval between cycles (days) 0.215  Normal (21–35) 745 (77.9) 640 (78.6) 105 (73.9)  Abnormal ( 35) 211 (22.1) 174 (21.4) 37 (26.1) Living 0.866  With family 780 (81.6) 664 (81.7) 116 (82.3)  In dormitories 174 (18.2) 149 (18.3) 25 (17.7) Univariate analysis for presence of dysmenorrhea among the study participants

A total of 956 questionnaires were returned to the researchers giving a response rate of approximately 80% which was higher than we expected. None of the students returned the questionnaire stating a diagnosed pathological condition. Medical students constituted 15.5% of the study sample while the majority (61.9%) were from the faculties of human and social sciences. The mean age of the participants was 19.73 ± 1.5 years and the majority (73.7%) were < 20 years old. More than two thirds (68.5%) of the participants had their first menarche when they were ≤14 years of age. The majority (74.1%) of the participants reported that their menstrual cycle was not regular in the past six months. Regarding the interval between cycles, the majority (77.9%) reported having an interval of 21–35 days between cycles. Two-thirds (65.6%) of the participants reported not doing exercise on their leisure time. The majority (81.6%) of participants were living with their families. Approximately 53.3% of the participants had a duration of menses of ≤5 days. When asked about parents’ level of education, the majority of participants reported that their parents had less than college education. Furthermore, the majority (71.5%) of participants reported that their families’ monthly income is ≤ average Palestinian monthly income (~ 800 USD). A small proportion (16.5%) of the participants was smokers. The majority (75.4%) of participants had normal BMI. Regarding the nutritional practices of the participants, only one forth (25.4%) of the participants reported having their breakfast on daily basis. Approximately two-thirds (67.4%) of the students reported taking ≥ two cups of caffeinated drinks daily. Based on their own assessment, 33.5% reported high consumption of salty foods, 30.4% reported high consumption of sweets, 10.4% reported high consumption of meats, and 12.5% reported high consumption of fruits and vegetables. A total of 814 (85.1%) females reported having pain during menstruation at least once in the past six months. This percentage is assumingly representing the prevalence of primary dysmenorrhea among the studied sample. The mean score of pain severity as assessed by visual analogue scale among dysmenorrhic students was 6.79 ± 2.64. Univariate analysis for the presence or absence of dysmenorrhea showed that the only significant difference between females with and those without dysmenorrhea was the age at menarche [( p  = 0.027; OR = 1.5, 95% CI (1.05–2.19)]. Students with dysmenorrhea reported various symptoms that accompany dysmenorrhea, most commonly as fatigue (61.4%) followed by nervousness (40%). Students with dysmenorrhea reported various degrees of pain in the visual analogue scale with 654 (80.34%) having moderate to severe pain and more than half 57.9% reported seeking medications such as paracetamol, NSAIDS, or anti-spasmodic to relieve pain. Regarding site of pain, supra-pubic (77.5%) and back pain (49%) were most frequently reported symptoms. For the duration of pain, the majority reported having pain in the first day of menses only (44.5%). Approximately less than one third (31.1%) reported missing the school in days of menstrual pain. When asked about family history (sister or mother), 73.8% reported a positive history of having painful dysmenorrhea (Table 2 ). Table 2 Most common symptoms associated with menstruation among female students with dysmenorrhea Variables Total number Percentage Site of pain  Suprapubic 631 77.5  Flank 191 23.5  Back 399 49  Thigh 221 27.1 Duration of pain  Few hours before menses 149 18.3  First day of menses only 362 44.5  From first to third day of menses 288 35.4  More than third day of menses 35 4.3 Severity of pain  Mild (≤4) 160 19.7  Moderate/severe(> 4) 654 80.3 College absenteeism  Yes 253 31.1  No 558 68.6 Medications  Yes 471 57.9  No 338 41.5 Category  Paracetamol 186 39.5  NSAIDs 219 46.5  Anti-spasmodic 11 2.34 Family  Yes 601 73.8  No 194 23.8 Associated symptoms  Diarrhea 95 11.7  Nausea 92 11.3  Vomiting 89 10.9  Fatigue 500 61.4  Dizziness 126 15.5  Headache 148 18.2  Breast tenderness 137 16.8  Nervousness 326 40  Insomnia 131 16.1  Arthralgia 233 28.6  None of the above 38 4.7 Most common symptoms associated with menstruation among female students with dysmenorrhea Univariate analysis for factors associated with moderate/severe pain among dysmenorrhic females were irregular cycle [( p  = 0.015); OR = 1.57, 95% CI = (1.09–2.30)], skipping breakfast [( p  < 0.001); OR = 1.93, 95% CI = (1.33–2.79)], academic specialization [( p  = 0.03; OR = 2.2, 95% CI = (1.21–3.98)] for medical specialization with reference to students in humanities), high stress level [( p  = 0.036; OR = 1.53, 95% CI = (1.03–2.28)], and living in dormitories [( p  = 0.034); OR = 1.72, 95% CI = (1.04–2.86)]. Students in the medical specialization had 2.2 odds of having moderate/severe dysmenorrhea compared to those in the faculties of human and social sciences. Students with irregular menses had 1.57 odds of having moderate/severe menses compared to students with regular menses. Students who reported to have an academic and life stress had 1.53 odds of having moderate/severe dysmenorrhea compared with students who reported no academic stress. Students living in dormitories have 1.72 odds of having moderate/severe dysmenorrhea compared with students living with their own families. Finally, students who do not have regular breakfast had 1.93 odds of having moderate/severe dysmenorrhea compared with students who had breakfast on regular basis (Table 3 ). Table 3 Univariate analysis for intensity of dysmenorrhic pain Variables Total (%) Mild (%) Moderate/severe (%) P value OR 95%(CI) College  E 182 (22.4) 36 (19.8) 146 (80.2) 0.03 1.12 (0.74–1.73)  H 507 (62.3) 110 (21.2) 397 (78.3) Reference  M 125 (15.4) 14 (11.2) 111 (88.8) 2.2 (1.21–3.98) Age(years)    14 245 (30.1) 57 (23.3) 188 (76.7) Regular  Always 213 (26.2) 54 (25.4) 159 (94.6) 0.015 Reference  Not always 601 (73.8) 106 (17.6) 495 (82.4) 1.57 (1.09–2.30) Duration of menses (days)   ≤ 5 429 (52.7) 94 (21.9) 335 (78.1) 0.087 –   > 5 385 (47.3) 66 (17.1) 319 (82.9) Education of the mother   ≤ High school 536 (65.8) 115 (21.8) 421 (78.5) 0.073 –   ≥ College 278 (34.2) 45 (16.2) 233 (83.8) Education of the father   ≤ High school 424 (52.1) 87 (20.5) 337 (79.5) 0.518 –   ≥ College 390 (47.9) 73 (18.7) 317 (81.3) Socioeconomic level   ≤ Average 580 (71.3) 113 (19.5) 467 (80.5) 0.845 –   > Average 234 (28.7) 47 (20.1%) 187 (79.7) Smoking  Yes 139 (17.1) 23 (16.5) 116 (83.5) 0.311 –  No 675 (82.9) 137 (20.3) 538 (79.7) Regular exercise  Yes 282 (34.6) 61 (21.6) 221 (87.4) 0.302 –  No 532 (65.4) 99 (18.6) 433 (81.4) Stress  Yes 249 (30.6) 38 (15.3) 211 (84.7) 0.036 1.53 (1.03–2.28)  No 565 (69.4) 122 (21.6) 443 (78.4) Reference Living  With family 664 (81.7) 140 (21.1) 524 (78.9) 0.034 Reference  In dormitory 149 (18.3) 20 (13.4) 129 (80.6) 1.72 (1.04–2.86) BMI    30 17 (2.2) 1 (5.9) 629 (80.7) Breakfast  Every day 207 (25.4) 58 (28) 149 (72) 0.001 Reference  Sometimes/never 607 (74.6) 102 (16.8) 505 (83.2) 1.93 (1.33–2.79) Vegetables and fruits  Never or low 172 (21.2) 26 (15.1) 146 (84.9) 0.069  Moderate 506 (62.3) 98 (19.4) 408 (80.6) –  High 104 (12.8) 25 (24) 79 (76)  Very high 30 (3.7) 10 (33.3) 20 (66.7) Meat and protein rich diet  Never or low 190 (23.4) 27 (14.2) 163 (85.8) 0.086  Moderate 517 (63.6) 113 (21.9) 404 (78.1) –  High 80 (9.8) 13 (16.3) 67 (83.8)  Very high 26 (3.2) 7 (26.9) 19 (73.1) Sweets and sugary beverages  Never or low 63 (7.7) 16 (25.4) 47 (74.6) 0.352  Moderate 452 (55.6) 87 (19.2) 365 (80.8) –  High 248 (30.5) 50 (20.2) 198 (79.8)  Very high 50 (6.2) 6 (12) 44 (88) Salty foods  Never or low 77 (9.5) 12 (15.6) 65 (84.4) 0.735  Moderate 387 (47.7) 80 (20.7) 307 (79.3) –  High 269 (33.1) 54 (20.1) 215 (79.9)  Very high 79 (9.7) 14 (17.7) 65 (82.3) Tea/coffee/Nescafe   ≤ 1 cup 264 (32.4) 49 (18.6) 215 (81.4) 0.589   ≥ 2 cup 550 (67.6) 111 (20.2) 439 (79.8) – Univariate analysis for intensity of dysmenorrhic pain Multivariate analysis of variables that showed significance in univariate analysis indicated that medical specialization [( p  = 0.045); OR = 1.92, 95% CI = (1.02–3.64)], skipping breakfast [( p  = 0.001); OR = 1.96, 95% CI = (1.35–2.86)], and irregular cycle [( p  = 0.022); OR = 1.56, 95% CI = (1.07–2.29)] were the only significant predictors of moderate/severe dysmenorrhic pain (Table 4 ). Table 4 Multivariate analysis for predictors of dysmenorrhic pain severity Variables Unstandardised Coefficients (B) Standardised Coefficients (Beta) P value 95% CI for B Academic specialization  Human and social Science Reference – – –  Medicine and Health Sciences 0.65 1.92 0.045 1.02–3.64  Science and Engineering 0.15 1.56 0.504 0.75–1.78 Regular menses  Yes Reference – – –  No 0.45 1.560 0.022 1.07–2.29 Breakfast  Yes Reference – – –  No 0.68 1.965 0.001 1.35–2.86 Stress  Yes Reference – – –  No 0.39 1.481 0.059 0.99–2.23 Living  With family Reference – – –  In dormitories 0.34 1.403 0.228 0.81–2.43 Multivariate analysis for predictors of dysmenorrhic pain severity Medical specialization is a weak but significant predictor of moderate/severe dysmenorrhea with an odds ratio of 1.92 (1.02–3.64) with reference to students in the faculties of human and social sciences. The second predictor was period regularity with students having irregular period had higher odds (1.65; 95% CI (1.07–2.29)) of having moderate/severe dysmenorrhea with reference to students with regular periods. The final predictor was having breakfast on daily basis where students who skipped breakfast tend to have higher odds (1.97; 95% CI (1.35–2.86) of having moderate/severe dysmenorrhea with reference to students who had their breakfast on daily basis.

Gynaecological problems among young females in Arab countries are not commonly studied due to social and cultural factors, which consider these problems a prohibited subject. For example, during the time interval from 2012 to 2016, only six articles about dysmenorrhea published in Arab countries were retrieved from Scopus database [ 1 – 6 ]. There has been an ongoing debate on the accurate definition of dysmenorrhea and that is one reason why the prevalence of dysmenorrhea across various studies varies considerably [ 7 ]. For example, two recently published studies considered dysmenorrhea as moderate to extreme pain during menstruation while others considered dysmenorrhea as having at least one episode of extreme pain during menstrual cycle [ 8 – 10 ]. However, the bulk of literature on prevalence of dysmenorrhea defined dysmenorrhea as painful menstrual uterine cramps regardless of severity [ 11 – 16 ]. A recent study on dysmenorrhea showed that there are different prevalence rates among females in different countries and different associated factors with dysmenorrhea or severity of pain [ 17 ]. Dysmenorrhea is broadly defined as pain during menstruation [ 18 ]. Most common symptoms of dysmenorrhea are pelvic or lower abdominal pain, back pain, diarrhoea, or nausea. These symptoms usually start at the time of menstruation and lasts within three days. Terms such as menstrual cramps or painful periods are also commonly used to describe these symptoms [ 19 , 20 ]. Dysmenorrhea has a negative impact on the quality of life of affected females. For example, dysmenorrhea might negatively affect relationships, academic and professional performance, and social and recreational activities [ 20 ]. Dysmenorrhea is classified as either primary or secondary dysmenorrhea. Primary dysmenorrhea usually occurs in adolescence shortly after menarche and is defined as painful menstruation without underlying macroscopic pelvic pathology [ 21 ]. Overproduction of uterine prostaglandins is the primary pathogenesis for primary dysmenorrhea [ 22 ]. Based on this pathogenesis, the most common medications used to relieve dysmenorrhic pain is non-steroidal anti-inflammatory drugs such as ibuprofen and diclofenac sodium [ 23 ]. Secondary dysmenorrhea, is mostly due to an identifiable pathological condition such as endometriosis or pelvic inflammatory disease. The onset of secondary dysmenorrhea usually occur after several years of menarche [ 21 ]. Reported risk factors for dysmenorrhea include earlier age at menarche, longer menstrual periods, heavier menstrual flow, and family history of dysmenorrhea [ 20 ]. Dysmenorrhea is an important public health problem among various ethnic groups and is associated with loss of school days and poor quality of life [ 24 – 26 ]. In Palestine, a small Arab country in the Middle East, published studies in women’s health in general and in gynaecological problems in particular are scarce. Studies about prevalence of dysmenorrhea and factors associated with it among university female students in Palestine is missing. Therefore, this study was undertaken to establish the prevalence and factors associated with dysmenorrhea among female university students in Palestine. The importance of this study is not only because it is the first in Palestine but also because the Palestinian females have been through a lot of psychological stress due to political stability and insecurity.

High proportion of female university female students had dysmenorrhea and more than half of dysmenorrhic females had moderate/sever pain and tend to skip academic classes because of painful menstruation. Among the various nutritional and life style factors investigated, skipping breakfast was the strongest predictor of severity of dysmenorrhic pain. Furthermore, the role of academic specialization as well as irregularity of menses as predictors of severity of dysmenorrhic pain need to be further investigated.

In this study, we aimed to determine the prevalence of dysmenorrhea and predictors of dysmenorrhic pain severity among female university students. The results of our study showed that the prevalence of dysmenorrhea was relatively high (85.1%) but fits within the reported values from developing and developed countries. Published studies showed variable rates of dysmenorrhea ranging from 34% in Egypt, 80% in Australia, 85% among hispanic female adolescents, and 94% in Oman [ 33 – 35 ]. Furthermore, studies showed that the prevalence of severe dysmenorrhic pain varies from 0.9% reported from Korea to 59.8% reported from Bangladesh [ 33 ]. It is difficult to explain and interpret variations in prevalence of dysmenorrhea. However, the use of different criteria for the definition of dysmenorrhea in different studies, culture, life style, genetics, and degree of social and personal stress are all potential reasons for variations in prevalence of dysmenorrhea [ 7 , 36 – 41 ]. There are several studies on prevalence of dysmenorrhea among female students published from Arab Middle Eastern countries. A cross-sectional study conducted in Dammam University (Kingdom of Saudi Arabia) revealed that about 35% of university females had severe dysmenorrhea [ 42 ]. A study among female medical students in Kingdom of Saudi Arabia showed that the prevalence of dysmenorrhea was 60.9%. An Egyptian study reported very high prevalence (94%) of dysmenorrhea among nursing students [ 43 ]. A study from Lebanon reported prevalence of dysmenorrhea of 74.3% [ 44 ]. Collectively, these studies confirm the variable nature of prevalence of dysmenorrhea among various female students in different Arab countries and even within the same country. In our study, the most common symptoms associated with dysmenorrhea were physical fatigue and emotional instability manifested as nervousness/irritability. Furthermore, our study showed that approximately 58% of dysmenorrhic students with moderate/severe pain opt to medications to decrease symptoms of painful menstruation. Similar results were obtained in a study published from Iran [ 45 ]. In Saudi Arabia, a study conducted among medical female students, the most common symptom that accompanied dysmenorrhea were depressed mood and anger [ 28 ]. A study in India indicated that a small proportion of dysmenorrhic students sought pharmacological management of the menstrual pain while the majority used herbal and other non-pharmacological approaches to decrease pain [ 46 ]. Seeking for medications or herbal remedies is a common feature among dysmenorrhic female students across most published studies. However, neither in our study nor in most published studies did the young females report seeking for medical intervention to treat dysmenorrhea. The predictors of dysmenorrhic pain severity had some overlap with the results published elsewhere. In our study, having breakfast was the strongest predictor of intensity of dysmenorrhic pain. The relationship between breakfast and intensity of pain during menstruation have been discussed by an article published from japan where the authors found that students who skip breakfast tends to have higher intensity of dysmenorrhic pain than those who had breakfast on regular basis [ 40 ]. Skipping food for cosmetic purposes during adolescence seems to have long term negative effects on reproductive function in young women [ 47 ]. Our study showed no relationship between BMI and dysmenorrhea or severity of pain. Similarly, no relationship was found between physical activity, smoking, consumption of salty or sweet food and dysmenorrhea or its pain intensity. Similar results were obtained by a study conducted in Nigeria where researchers reported no significant relationship between dysmenorrhea or its pain intensity with factors such as BMI, waist circumference, and physical activity [ 48 ]. A contradictory effect of physical activity on dysmenrrhea was found by a study in Iran [ 49 ]. A comprehensive review on the role of physical activity in reducing dysmenorrhea and its pain intensity found little effect but further studies on this issue are needed [ 50 ]. Our study showed that the academic specialization was a significant, although weak, predictor of the intensity of dysmenorrhea pain. Several studies were carried out about dysmenorrhea among medical female students since they are under a lot of academic pressure and have to attend the hospital at difficult times. Most of these studies reported high prevalence of dysmenorrhea among medical female students [ 4 , 51 – 55 ]. Our study, although the first in Palestine has few limitations that need to be listed. This study is a cross sectional one which limits the causality interpretation. Second, the sample size was large but was obtained from one university in North of Palestine. Larger studies that include young females from all regions in Palestine are needed. Some of the variables in the study, such as nutrition and physical activity ones, might not be well defined and overlap of answers is a possibility which limits the interpretation of data. The definition of dysmenorrhea used in this study, which is any painful menstruation in the past six months, might not be an accurate one. Students with mild pain might be considered by others as normal menstrual cramping. Despite these limitations, our study could be used to increase awareness among female students regarding dysmenorrhea in general and predictors of dysmenorrhic pain severity in particular.