Endometriose des Colon transversum

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This case describes a 65-year-old woman diagnosed with transverse colon endometriosis, presenting as a polyp-like structure, which required surgical resection to rule out malignancy.

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This article reports a case of a 65-year-old woman who underwent colonoscopy without complaints due to family history of colorectal cancer and who had received estrogen therapy for postmenopausal complaints. Colonoscopy identified a 2×2 cm polyp-like transverse colon lesion with central tissue proliferation, but chromoendoscopy and multiple biopsies did not show adenomatous glandular proliferation; miniendosonography suggested a tumor in the muscularis propria. Because malignancy could not be excluded, laparoscopic colon segment resection was performed, and histology showed intramural extragenital endometriosis in the muscularis propria with nodular proliferation of local muscle and ectopic endometrial glands showing complex hyperplasia without atypia, consistent with estrogen stimulation. This paper is centrally about endometriosis — specifically intestinal endometriosis of the transverse colon with intramural (muscularis propria) localization.

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Abstract

HISTORY: A 65-year-old woman with no complaints came to our hospital for a colonoscopy because of a family history of a colorectal carcinoma. Because of postmenopausal complaints she had been undergoing estrogen therapy for the past five years. INVESTIGATIONS: Colonoscopy revealed a 2 x 2 cm polyp like structure with central tissue proliferation in the transverse colon. Neither chromoendoscopy with indigocarmine nor multiple biopsies indicated an adenomatous glandular proliferation. Miniendosonography revealed the image of a tumour located in the muscularis propria. DIAGNOSIS AND CLINICAL COURSE: As a malign process could not definitely be excluded, a colon segment resection was carried out by laparoscopy. In the operative specimen there was a 2 x 2 cm large tumour growing under the mucosa. Histologically it was an intramural manifestation of an extragenital endometriosis in the area of the muscularis propria with resulting nodular proliferation of the local muscle system. The ectopic endometrial glands in the area of the endometriosis revealed a complex hyperplasia without atypical features, an image suggesting oestrogen stimulation. CONCLUSION: In many cases the diagnosis of an intestinal endometriosis can not be made through a non-invasive diagnostic method such as colonoscopy with biopsy because of the intramural localisation in the muscularis propria. In order to safely rule out a malignant lesion, in unclear cases a resection should be aimed at.
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Subscribe to RSS DOI: 10.1055/s-2002-35180 Endometriose des Colon transversum Eine seltene LokalisationEndometriosis of the transverse colon A rare localizationPublication History eingereicht: 21.6.2002 akzeptiert: 22.9.2002 Publication Date: 31 October 2002 (online) Anamnese und klinischer Befund: Eine 65-jährige Patientin stellte sich beschwerdefrei aufgrund einer familiären Belastung bezüglich eines kolorektalen Karzinoms zur Koloskopie in unserer Klinik vor. Wegen postmenopausaler Beschwerden bestand seit 5 Jahren eine Östrogentherapie. Untersuchungen: In der Koloskopie zeigte sich im Colon transversum eine 2 × 2 cm große polypoide Struktur mit zentraler Gewebsproliferation. Weder die Chromoendoskopie mit Indigocarmin noch multiple Biopsien ergaben Hinweise für eine adenomatöse Drüsenproliferation. Miniendosonographisch bot sich das Bild eines in der Muscularis propria gelegenen Tumors. Diagnose und Verlauf: Da durch die durchgeführte Diagnostik ein maligner Prozess nicht sicher ausgeschlossen werden konnte, erfolgte eine laparoskopische Kolonsegmentresektion. Im Resektat fand sich ein 2 × 2 cm großer, die Schleimhaut unterminierend wachsender Tumor. Histologisch handelte es sich um eine intramurale Manifestation einer extragenitalen Endometriose im Bereich der Muscularis propria mit konsekutiver nodulärer Proliferation der ortsständigen Muskulatur. Folgerung: In vielen Fällen kann die Diagnose einer intestinalen Endometriose aufgrund der intramuralen Lokalisation in der Muscularis propria durch eine nicht invasive Diagnostik wie Koloskopie mit Biopsie nicht gestellt werden. Um eine maligne Läsion sicher auszuschließen, sollte in unklaren Fällen eine Resektion angestrebt werden. History: A 65-year-old woman with no complaints came to our hospital for a colonoscopy because of a family history of a colorectal carcinoma. Because of postmenopausal complaints she had been undergoing estrogen therapy for the past five years. Investigations: Colonoscopy revealed a 2 × 2 cm polyp like structure with central tissue proliferation in the transverse colon. Neither chromoendoscopy with indigocarmine nor multiple biopsies indicated an adenomatous glandular proliferation. Miniendosonography revealed the image of a tumour located in the muscularis propria. Diagnosis and clinical course: As a malign process could not definitely be excluded, a colon segment resection was carried out by laparoscopy. In the operative specimen there was a 2 × 2 cm large tumour growing under the mucosa. Histologically it was an intramural manifestation of an extragenital endometriosis in the area of the muscularis propria with resulting nodular proliferation of the local muscle system. The ectopic endometrial glands in the area of the endometriosis revealed a complex hyperplasia without atypical features, an image suggesting oestrogen stimulation. Conclusion: In many cases the diagnosis of an intestinal endometriosis can not be made through a non-invasive diagnostic method such as colonoscopy with biopsy because of the intramural localisation in the muscularis propria. In order to safely rule out a malignant lesion, in unclear cases a resection should be aimed at. Literatur - 1 Afdhal N H, Smith J, Heffernan S, Doyle J S, Gaffney E. Acute small bowel obstruction secondary to endometriosis: two case reports and rewiew of the literature. Ir Med J. 1984; 77 141-143 - 2 Athmanathan N, Sehdev V K, Walsh T H. Endometriosis of the sigmoid colon: a diagnostic problem. Br J Clin Pract. 1990; 44 658-660 - 3 Canto M I, Setrakian S, Petras R E, Blades E, Chak A, Sivak M V. Methylene blue selectively stains intestinal metaplasia in Barrett`s esophagus. Gastrointest Endosc. 1996; 44 1-7 - 4 Canto M I, Setrakian S, Willis J E, Chak A, Petras R E, Sivak M V. Methylene blue staining of dysplastic and nondysplastic Barrett`s esophagus: An in vivo and ex vivo study. Endoscopy. 2001; 33 391-400 - 5 Halme J, Hammond M G, Hulka J F. et al . Retrograde menstruation in healthy women and in patients with endometriosis. Obstet Gynecol. 1984; 64 151-154 - 6 Harty R F, Kaude J V. Invasive endometriosis of the terminal ileum: a cause of small bowel obstruction of obscure origin. South Med J. 1983; 76 253-255 - 7 Honore G M. Extrapelvic endometriosis. Clin Obstet Gynecol. 1999; 42 699-711 - 8 Hunerbein M, Totkas S, Ghadimi B M, Schlag P M. Preoperative evaluation of colorectal neoplasms by colonoscopic miniprobe ultrasonography. Ann Surg. 2000; 232 46-50 - 9 Insabato L, D’Armiento F P, Tornillo L. A rectal endometrioma producing intestinal obstruction. J Clin Gastroenterol. 1994; 19 82-4 - 10 Kato S, Fujii T, Koba I, Sano Y, Fu K I, Parra-Blanco A, Tajiri H, Yoshida S, Rembacken B. Assessment of colorectal lesions using magnifying colonoscopy and mucosal dye spraying: Can significant lesions be distinguished?. Endoscopy. 2001; 33 306-310 - 11 Körber J, Grammel S, Lobeck H, Weidemann H. Stenose des terminalen Ileum. Endometriose als Differentialdiagnose des Morbus Crohn. Dtsch Med Wochenschr. 1997; 122 926-929 - 12 Kudo S, Rubio C, Teixeira C R, Kashida H, Kogure E. Pit Pattern in colorectal neoplasia: endoscopic magnifying view. Endoscopy. 2002; 33 367-373 - 13 Kudo S, Tamura S, Nakajima T, Yamano H, Kusaka H, Watanabe H. Diagnosis of colorectal tumorous lesions by magnifying endoscopy. Gastrointest Endosc. 1996; 44 8-14 - 14 Langlois N EI, Park K GM, Keenan R A. Mucosal Changes in the large bowel with endometriosis. Aut N Z J Surg. 1989; 59 941-943 - 15 Mahmood T A, Templeton A. Prevalence and genesis of endometriosis. Hum Reprod. 1991; 6 544-549 - 16 Mittermair R P, Prommegger R, Zelger B G, Bodner E. Darminvagination durch Endometriose des terminalen Ileum. Dtsch Med Wochenschr. 1999; 124 1522-1524 - 17 Prystowsky J B, Stryker S J, Ujiki G T, Poticha S M. Gastrointestinal endometriosis: incidence and indications for resection. Arch Surg. 1988; 123 855-858 - 18 Tamada K, Ueno N, Tomiyama T. et al . Characterization of biliary strictures using intraductal ultrasonography: Comparison with percutaneus cholangioscopic biopsy. Gastrointest Endosc. 1998; 47 341-349 - 19 Weed J C, Ray J E. Endometriosis of the bowel. Obstet Gynecol. 1987; 69 727-730 - 20 Witz C A. Current concepts in the pathogenesis of endometriosis. Clin Obstet Gynol. 1999; 42 566-585 Dr. med. Dieter Schilling Medizinische Klinik C, Klinikum der Stadt Ludwighafen gGmbH Bremserstraße 79 67063 Ludwigshafen am Rhein Phone: 0621/5034100 Fax: 0621/5034114 Email: [email protected]

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Condition tags

endometriosis

MeSH descriptors

Colonic Diseases Endometriosis Adenomatous Polyposis Coli Adenomatous Polyposis Coli Adenomatous Polyposis Coli Adenomatous Polyposis Coli Aged Biopsy Colon Colon Colonic Diseases Colonic Diseases Colonic Diseases Colonoscopy Diagnosis, Differential Endometriosis Endometriosis Endometriosis Endosonography Female

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chemicals 2
estrogen indigoidine

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