Clear cell adenocarcinoma arising in endometriosis of a previous episiotomy site

Kwon YS, Yong-Soon Kwon, Joo-Hyun Nam, Nam JH, Choi G, Gawon Choi
Obstetrics and gynecology · 2008 · doi:10.1097/AOG.0b013e318179475b · PMID:18669770
case-report OA: closed public-domain-us
Full text JSON View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-08-03 ⓘ

A 42-year-old woman developed clear cell adenocarcinoma arising in endometriosis at a previous episiotomy site, which was successfully treated with radical surgery.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-22 · read from full text ⓘ

This case report describes a 42-year-old woman who developed clear cell adenocarcinoma within an episiotomy scar site, three years after previous excision of an endometriotic cyst and treatment with gonadotropin-releasing hormone analogues. The patient presented with a palpable mass near the posterior vaginal commissure, and biopsy confirmed malignant transformation of the residual endometriosis into clear cell adenocarcinoma. She underwent radical surgery without adjuvant therapy and showed no evidence of recurrence at the ten-month follow-up evaluation. This paper is centrally about endometriosis — specifically the rare malignant transformation of extragonadal endometriosis located in a previous episiotomy site.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

BACKGROUND: Malignant transformation of endometriosis in an episiotomy site is rare. CASE: A 42-year-old woman presented with a palpable mass, 2.5 cm in size, just inside the posterior commissure of the vagina, at the site of a previous episiotomy for a vaginal delivery. Three years previously, an endometriotic cyst had been excised at the same site, and the patient had been treated with a gonadotropin-releasing hormone analogue for 6 months. Biopsy revealed a clear cell adenocarcinoma arising in endometriosis. The patient underwent radical surgery alone without adjuvant therapy. At 10-month follow-up, there was no evidence of recurrence. CONCLUSION: Patients who experience a recurrence of extragonadal endometriosis after prior therapy should be monitored carefully for malignant degeneration.
Full text 929 characters · extracted from oa-doi-fallback · 2 sections · click to expand

Background

Malignant transformation of endometriosis in an episiotomy site is rare. CASE: A 42-year-old woman presented with a palpable mass, 2.5 cm in size, just inside the posterior commissure of the vagina, at the site of a previous episiotomy for a vaginal delivery. Three years previously, an endometriotic cyst had been excised at the same site, and the patient had been treated with a gonadotropin-releasing hormone analogue for 6 months. Biopsy revealed a clear cell adenocarcinoma arising in endometriosis. The patient underwent radical surgery alone without adjuvant therapy. At 10-month follow-up, there was no evidence of recurrence.

Conclusion

Patients who experience a recurrence of extragonadal endometriosis after prior therapy should be monitored carefully for malignant degeneration.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Endometriosis Episiotomy Iatrogenic Disease Vulvar Neoplasms Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adult Endometriosis Endometriosis Endometriosis Episiotomy Female Humans Vulvar Neoplasms Vulvar Neoplasms Vulvar Neoplasms

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

europepmc
last seen: 2026-09-20T09:27:46.357103+00:00
pubmed
last seen: 2026-05-13T22:14:30.652814+00:00
unpaywall
last seen: 2026-05-14T19:30:52.867331+00:00
License: public-domain-us · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine