Serum anti-Müllerian hormone levels are lower in reproductive-age women with Crohn's disease compared to healthy control women

Ebubekir Şenateş, Yaşar Çolak, Emrullah Erdem, Emrullah Düzgün Erdem, Atakan Yeşil, Atakan Yeşıl, Ender Coşkunpınar, Ender Çoşkunpınar, Önder Şahin, Mustafa Erhan Altunöz, İlyas Tuncer, Ayşe Oya Kurdaş Övünç, Ayşe O Kurdaş Övünç
Journal of Crohn's & colitis · 2012 · vol. 7(2) , pp. e29–e34 · doi:10.1016/j.crohns.2012.03.003 · PMID:22472089 · W2094061333
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Reproductive-age women with Crohn's disease have significantly lower serum anti-Müllerian hormone levels compared to healthy controls, with higher disease activity correlating with lower AMH.

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Abstract

BACKGROUND AND AIM: Crohn's disease (CD) decreases fertility both directly, by inducing inflammation in the fallopian tubes and ovaries, and indirectly, through the surgical interventions and tubal adhesions associated with disease treatment. Anti-müllerian hormone (AMH) is a reliable indicator of ovarian reserve in women. We aimed to compare serum AMH levels between reproductive-age women with CD and healthy controls. METHODS: Serum AMH levels were measured by ELISA in 35 women with CD and 35 age-matched healthy women controls. RESULTS: CD patients and controls were similar in terms of age, height, weight and BMI. Mean CD duration was 60 months. CRP, ESR and leukocyte counts were significantly higher in CD patients compared to the controls (p<0.001, p=0.004 and p=0.04, respectively). AMH levels in CD patients (1.02 ± 0.72) were significantly lower compared to the controls (1.89 ± 1.80) (p = 0.009). Serum AMH levels in CD patients with active disease (0.33 ± 0.25) were significantly lower compared to CD patients who were in remission (1.53 ± 0.49) (p = 0.001). Serum AMH levels were similar in CD patients with a disease duration of less than 5 years (17 patients) and CD patients with a disease duration of greater than 5 years (18 patients) (p = 0.8). In CD patients, a negative correlation between CDAI and serum AMH levels was found (r = -0.718, p < 0.001). Serum AMH levels were similar in CD patients who had (6 patients) and had not undergone (29 patients) surgical treatment (p = 0.2). CONCLUSION: Serum AMH levels of reproductive-age women with CD were significantly lower compared to the controls. CDAI and AMH are inversely correlated.

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MeSH descriptors

Anti-Mullerian Hormone Crohn Disease Adult Anti-Mullerian Hormone Blood Sedimentation Case-Control Studies C-Reactive Protein C-Reactive Protein Crohn Disease Crohn Disease Cross-Sectional Studies Female Humans Leukocyte Count Ovary Ovary Severity of Illness Index Statistics, Nonparametric Time Factors Young Adult

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