Endometrial and embryonic enzymes in relation to implantation of the rabbit blastocyst

E. S. E. Hafez, I. G. White
In: The Anatomical Record · 1967 · vol. 159(3) , pp. 273–279 · doi:10.1002/ar.1091590305 · PMID:6082102 · W2045248878
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This study measured endometrial and embryonic enzyme activities in rabbits during estrus, pseudopregnancy, and early pregnancy, identifying changes in SDH, GDH, and amylase as key indicators related to implantation.

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Abstract

Abstract The activity of alkaline phosphatase, acid phosphatase, glutamic‐oxalacetic transaminase (GOT), lactic dehydrogenase (LDH), amylase, succinic dehydrogenase (SDH), glucose‐6‐phosphate dehydrogenase (GD) has been determined in the rabbit endometrium at estrus, in pseudopregnancy, and at days 5–10 of pregnancy. Enzyme analyses were also made on the placenta and embryo during early pregnancy. The most striking changes were increases in the SDH and GDH levels of the endometrium and a decrease in amylase when the does became pregnant or pseudopregnant. Amylase did not rise significantly from its lower level between five and ten days of pregnancy; SDH and GDH activity, however, fell away after reaching a maximum prior to implantation. At implantation there was some evidence of an increase in LDH and phosphatase activity. All enzymes had lower activities following implantation (10 days pregnancy). The endometrial enzyme activities of prepubertal does were usually similar to those of adult females in estrus. However, alkaline phosphatase activity of the prepubertal endometrium was particularly low. The activity of enzymes in the placental areas were, in general, similar to those found in the interplacental areas of the endometrium. However, from 7–10 days of pregnancy the activity of SDH was lower in the placental area than in the interplacental areas; whereas, amylase was higher on the eighth and ninth days of pregnancy. Changes in the activities of the phosphatases, GOT and SDH occurred in the blastocyst and trophoblast on eight to ten days of pregnancy. Enzyme activities in blastocoelic fluid were much less than in the trophoblast with the exception of amylase which was higher.

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