Histological and clinical features of menstruation induced by the antiprogestin mifepristone (RU486) compared to menstruation occurring spontaneously

Tin Chiu Li, Peter Dockery, Andrew W. Rogers, Ian Cooke
In: Journal of Obstetrics and Gynaecology · 1990 · vol. 10(5) , pp. 411–414 · doi:10.3109/01443619009151233 · PMID:12283861 · W2159333241
article OA: closed CC0
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-11 ⓘ

Mifepristone-induced menstruation did not differ in amount or duration from spontaneous menstruation, suggesting similar hemostatic mechanisms, and was associated with reduced glandular secretory activity and predecidual reaction.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

SummaryThe amount and duration of menstruation induced by a single oral dose of mifepristone (RU38486 or RU486) given in the first half of the luteal phase did not differ from spontaneous menstruation, suggesting that the haemostatic mechanisms are similar. With endometrial biopsy specimens, menstruation induced by mifepristone, was associated with a reduction of the amount of glandular secretory activity, predecidual reaction and leucocytic infiltration, implying that these processes may not be essential for menstruation. The amount of predecidual reaction at the time of induced menstruation was found to be reduced in those who subsequently had further bleeding around the expected time of menstruation for that cycle when compared to those who did not. Predecidual reaction, though not a prerequisite for endometrial bleeding, may be closely related to endometrial shedding at the time of menstruation.

My notes (saved in your browser only)

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (1)

References (8)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK