Adenylate cyclase from human decidua parietalis

J A Whitsett; Jeffrey A. Whitsett; Carl L. Johnson; C L Johnson

doi:10.1016/0002-9378(79)90280-1

Adenylate cyclase from human decidua parietalis

J A Whitsett, Jeffrey A. Whitsett, Carl L. Johnson, C L Johnson

American journal of obstetrics and gynecology · 1979 · vol. 133(5) , pp. 479–483 · doi:10.1016/0002-9378(79)90280-1 · PMID:443285 · W1656139744

Lab / animal OA: closed CC0

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This study demonstrates that adenylate cyclase activity is specific to human decidua parietalis membranes and is stimulated by prostaglandins E1, E2, fluoride, and guanosine triphosphate.

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Abstract

Adenylate cyclase (EC 4.6.1.1) activity was demonstrated in membrane fractions of human decidua parietalis. Adenylate cyclase activity was associated with membrane fractions of decidua but not chorion or amnion. Prostaglandins PGE1 and PGE2 but neither PGD2 nor PGF2 alpha stimulated this activity at gestational ages 18 to 40 weeks. Fluoride and guanosine triphosphate stimulated decidual adenylate cyclase; however, epinephrine-stimulated adenylate cyclase activity was demonstrable only in the presence of guanosine triphosphate. The possible roles of adenylate cyclase activity in the decidua are discussed.

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MeSH descriptors

Adenylyl Cyclases Decidua Adenylyl Cyclases Amnion Amnion Chorion Chorion Decidua Decidua Dose-Response Relationship, Drug Epinephrine Epinephrine Ethanol Ethanol Female Fluorides Fluorides Guanosine Triphosphate Guanosine Triphosphate Humans

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (1)

RELEASE OF LYSOSOMAL ACID PHOSPHATASE INTO THE CYTOPLASM OF DECIDUAL CELLS BEFORE THE ONSET OF LABOUR IN HUMANS 1975

References (21)

RELEASE OF LYSOSOMAL ACID PHOSPHATASE INTO THE CYTOPLASM OF DECIDUAL CELLS BEFORE THE ONSET OF LABOUR IN HUMANS via openalex
W1609231949 via openalex
W1645539478 via openalex
W1897633092 via openalex
W1952575201 via openalex
W1974855626 via openalex
W1978402783 via openalex
W1987670049 via openalex
W1996732665 via openalex
W1996858676 via openalex
W2052240378 via openalex
W2096552205 via openalex
W2122385136 via openalex
W2169503005 via openalex
W2257112383 via openalex
W2637385452 via openalex
W6636539739 via openalex
W6645044181 via openalex
W6649503534 via openalex
W1529393278 via openalex
W6678014641 via openalex

SciLite annotations

organisms 2

human human

chemicals 5

prostaglandin fluoride guanosine 5'-monophosphate adrenaline guanosine 5'-monophosphate

Source provenance

openalex: last seen: 2026-06-10T17:14:06.276822+00:00
pubmed: last seen: 2026-10-08T21:57:21.703920+00:00
scilite: last seen: 2026-05-18T04:57:49.680383+00:00

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[1] RELEASE OF LYSOSOMAL ACID PHOSPHATASE INTO THE CYTOPLASM OF DECIDUAL CELLS BEFORE THE ONSET OF LABOUR IN HUMANS 1975