Top quality embryos at day 2: a prerequisite for single blastocyst transfer? An observational cohort study in women under 36.
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This observational cohort study of women under 36 found that single blastocyst transfer yielded higher cumulative delivery rates when at least two top-quality day 2 embryos were present, supporting the strategy regardless of initial embryo quality.
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Abstract
PurposeWhile extended culture has been considerably improved, some questions remain regarding the application of Single Blastocyst Transfer (SBT).MethodsAn observational cohort study was undertaken with 456 women under 36 years old and assigned to SBT on a voluntary basis. The main outcome was the cumulative delivery rate per couple according to the number of Top Quality Embryos (TQE) on day 2 (Group 1= > or =2 TQE, Group 2= 1 TQE and Group 3= 0 TQE).ResultsRate of transfer and mean number of frozen blastocyts were higher in Group 1 compared to Group 3. As a consequence, the cumulative delivery rate per couple was higher in Group 1 (47.9%) compared to Group 3 (34.9%).ConclusionsSingle blastocyst transfer combining fresh and frozen cycles, might be a worthwhile strategy irrespective of embryo quality on day 2 providing good delivery rates while keeping the rate of multiple deliveries low.
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- europepmc
- last seen: 2026-09-13T09:25:22.628771+00:00